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10.1111/imm.12806 http://scihub22266oqcxt.onion/10.1111/imm.12806 28763099!5680052!28763099     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28763099&cmd=llinks): Failed to open stream: HTTP request failed! 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Autologous tolerogenic dendritic cells derived from monocytes of systemic lupus erythematosus patients and healthy donors show a stable and immunosuppressive phenotype |pdf=|usr=}}{{28763099}} gab.com Text Autologous tolerogenic dendritic cells derived from monocytes of systemic lupus erythematosus patients and healthy donors show a stable and immunosuppressive phenotype JO: Immunology http://www.kidney.de/pget.php?&tw=1&pmid=28763099 #FOAvip Systemic lupus erythematosus (SLE) is an autoimmune disease with unrestrained T-cell and B-cell activity towards self-antigens. Evidence shows that apoptotic cells (ApoCells) trigger an autoreactive response against nuclear antigens in susceptible individuals. In this study, we focus on generating and characterizing tolerogenic dendritic cells (tolDCs) to restore tolerance to ApoCells. Monocyte-derived dendritic cells (DCs) from healthy controls and patients with SLE were treated with dexamethasone and rosiglitazone to induce tolDCs. Autologous apoptotic lymphocytes generated by UV irradiation were given to tolDCs as a source of self-antigens. Lipopolysaccharide (LPS) was used as a maturation stimulus to induce the expression of co-stimulatory molecules and secretion of cytokines. TolDCs generated from patients with SLE showed a reduced expression of co-stimulatory molecules after LPS stimulation compared with mature DCs. The same phenomenon was observed in tolDCs treated with ApoCells and LPS. In addition, ApoCell-loaded tolDCs stimulated with LPS secreted lower levels of interleukin-6 (IL-6) and IL-12p70 than mature DCs without differences in IL-10 secretion. The functionality of tolDCs was assessed by their capacity to prime allogeneic T cells. TolDCs displayed suppressor properties as demonstrated by a significantly reduced capacity to induce allogeneic T-cell proliferation and activation. ApoCell-loaded tolDCs generated from SLE monocytes have a stable immature/tolerogenic phenotype that can modulate CD4(+) T-cell activation. These properties make them suitable for an antigen-specific immunotherapy for SLE. Twit Text FOAVip Autologous tolerogenic dendritic cells derived from monocytes of systemic lupus erythematosus patients and healthy donors show a stable and immunosuppressive phenotype ????Immunology http://www.kidney.de/pget.php?&tw=1&pmid=28763099 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28763099 #FOAvip English Wikipedia <ref>{{Cite pmid|28763099}}</ref> Autologous tolerogenic dendritic cells derived from monocytes of systemic lupus erythematosus patients and healthy donors show a stable and immunosuppressive phenotype #MMPMID28763099 Obreque J; Vega F; Torres A; Cuitino L; Mackern-Oberti JP; Viviani P; Kalergis A; Llanos C Immunology 2017[Dec]; 152 (4): 648-659 PMID28763099show ga Systemic lupus erythematosus (SLE) is an autoimmune disease with unrestrained T-cell and B-cell activity towards self-antigens. Evidence shows that apoptotic cells (ApoCells) trigger an autoreactive response against nuclear antigens in susceptible individuals. In this study, we focus on generating and characterizing tolerogenic dendritic cells (tolDCs) to restore tolerance to ApoCells. Monocyte-derived dendritic cells (DCs) from healthy controls and patients with SLE were treated with dexamethasone and rosiglitazone to induce tolDCs. Autologous apoptotic lymphocytes generated by UV irradiation were given to tolDCs as a source of self-antigens. Lipopolysaccharide (LPS) was used as a maturation stimulus to induce the expression of co-stimulatory molecules and secretion of cytokines. TolDCs generated from patients with SLE showed a reduced expression of co-stimulatory molecules after LPS stimulation compared with mature DCs. The same phenomenon was observed in tolDCs treated with ApoCells and LPS. In addition, ApoCell-loaded tolDCs stimulated with LPS secreted lower levels of interleukin-6 (IL-6) and IL-12p70 than mature DCs without differences in IL-10 secretion. The functionality of tolDCs was assessed by their capacity to prime allogeneic T cells. TolDCs displayed suppressor properties as demonstrated by a significantly reduced capacity to induce allogeneic T-cell proliferation and activation. ApoCell-loaded tolDCs generated from SLE monocytes have a stable immature/tolerogenic phenotype that can modulate CD4(+) T-cell activation. These properties make them suitable for an antigen-specific immunotherapy for SLE. |*Tissue Donors[MESH] |Adult[MESH] |Aged[MESH] |Autografts[MESH] |Dendritic Cells/immunology/*transplantation[MESH] |Female[MESH] |Humans[MESH] |Immunosuppression Therapy/*methods[MESH] |Interleukin-10/immunology[MESH] |Interleukin-12/immunology[MESH] |Interleukin-6/immunology[MESH] |Lipopolysaccharides/pharmacology[MESH] |Lupus Erythematosus, Systemic/immunology/pathology/*therapy[MESH] |Lymphocytes/immunology[MESH] |Male[MESH] |Middle Aged[MESH] |Monocytes/immunology/*transplantation[MESH]Autologous tolerogenic dendritic cells derived from monocytes of syste(epmc).pdf DeepDyve Pubget Overpricing