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10.1016/j.immuni.2017.07.016 http://scihub22266oqcxt.onion/10.1016/j.immuni.2017.07.016 28801234!5564225!28801234     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28801234&cmd=llinks): Failed to open stream: HTTP request failed! 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Dendritic Cells but Not Macrophages Sense Tumor Mitochondrial DNA for Cross-priming through Signal Regulatory Protein alpha Signaling |pdf=|usr=}}{{28801234}} gab.com Text Dendritic Cells but Not Macrophages Sense Tumor Mitochondrial DNA for Cross-priming through Signal Regulatory Protein alpha Signaling JO: Immunity http://www.kidney.de/pget.php?&tw=1&pmid=28801234 #FOAvip Inhibition of cytosolic DNA sensing represents a strategy that tumor cells use for immune evasion, but the underlying mechanisms are unclear. Here we have shown that CD47-signal regulatory protein alpha (SIRPalpha) axis dictates the fate of ingested DNA in DCs for immune evasion. Although macrophages were more potent in uptaking tumor DNA, increase of DNA sensing by blocking the interaction of SIRPalpha with CD47 preferentially occurred in dendritic cells (DCs) but not in macrophages. Mechanistically, CD47 blockade enabled the activation of NADPH oxidase NOX2 in DCs, which in turn inhibited phagosomal acidification and reduced the degradation of tumor mitochondrial DNA (mtDNA) in DCs. mtDNA was recognized by cyclic-GMP-AMP synthase (cGAS) in the DC cytosol, contributing to type I interferon (IFN) production and antitumor adaptive immunity. Thus, our findings have demonstrated how tumor cells inhibit innate sensing in DCs and suggested that the CD47-SIRPalpha axis is critical for DC-driven antitumor immunity. Twit Text FOAVip Dendritic Cells but Not Macrophages Sense Tumor Mitochondrial DNA for Cross-priming through Signal Regulatory Protein alpha Signaling ????Immunity http://www.kidney.de/pget.php?&tw=1&pmid=28801234 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28801234 #FOAvip English Wikipedia <ref>{{Cite pmid|28801234}}</ref> Dendritic Cells but Not Macrophages Sense Tumor Mitochondrial DNA for Cross-priming through Signal Regulatory Protein alpha Signaling #MMPMID28801234 Xu MM; Pu Y; Han D; Shi Y; Cao X; Liang H; Chen X; Li XD; Deng L; Chen ZJ; Weichselbaum RR; Fu YX Immunity 2017[Aug]; 47 (2): 363-373.e5 PMID28801234show ga Inhibition of cytosolic DNA sensing represents a strategy that tumor cells use for immune evasion, but the underlying mechanisms are unclear. Here we have shown that CD47-signal regulatory protein alpha (SIRPalpha) axis dictates the fate of ingested DNA in DCs for immune evasion. Although macrophages were more potent in uptaking tumor DNA, increase of DNA sensing by blocking the interaction of SIRPalpha with CD47 preferentially occurred in dendritic cells (DCs) but not in macrophages. Mechanistically, CD47 blockade enabled the activation of NADPH oxidase NOX2 in DCs, which in turn inhibited phagosomal acidification and reduced the degradation of tumor mitochondrial DNA (mtDNA) in DCs. mtDNA was recognized by cyclic-GMP-AMP synthase (cGAS) in the DC cytosol, contributing to type I interferon (IFN) production and antitumor adaptive immunity. Thus, our findings have demonstrated how tumor cells inhibit innate sensing in DCs and suggested that the CD47-SIRPalpha axis is critical for DC-driven antitumor immunity. |Animals[MESH] |Antibodies, Blocking/therapeutic use[MESH] |Antigens, Differentiation/*metabolism[MESH] |CD47 Antigen/immunology/metabolism[MESH] |Cells, Cultured[MESH] |Colonic Neoplasms/genetics/*immunology/therapy[MESH] |Cross-Priming[MESH] |DNA, Mitochondrial/*immunology[MESH] |Dendritic Cells/*immunology[MESH] |Disease Models, Animal[MESH] |Humans[MESH] |Interferon Type I/metabolism[MESH] |Macrophages/immunology[MESH] |Membrane Glycoproteins/metabolism[MESH] |Membrane Proteins/genetics/*metabolism[MESH] |Mice[MESH] |Mice, Inbred C57BL[MESH] |Mice, Knockout[MESH] |NADPH Oxidase 2[MESH] |NADPH Oxidases/metabolism[MESH] |Nucleotidyltransferases/metabolism[MESH] |Receptors, Immunologic/*metabolism[MESH] |Signal Transduction[MESH]Dendritic Cells but Not Macrophages Sense Tumor Mitochondrial DNA for (epmc).pdf DeepDyve Pubget Overpricing