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10.1111/1440-1681.12848 http://scihub22266oqcxt.onion/10.1111/1440-1681.12848 28853207!�!28853207 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28853207&cmd=llinks): Failed to open stream: HTTP request failed! 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Curcumin ameliorates severe influenza pneumonia via attenuating lung injury and regulating macrophage cytokines production |pdf=|usr=}}{{28853207}} gab.com Text Curcumin ameliorates severe influenza pneumonia via attenuating lung injury and regulating macrophage cytokines production JO: Clin Exp Pharmacol Physiol http://www.kidney.de/pget.php?&tw=1&pmid=28853207 #FOAvip Curcumin, an active phenolic agent extract from the Curcuma longa, exhibits excellent anti-cancer, anti-inflammation, and neuroprotective effects. We aimed to investigate the anti-influenza role of curcumin in vitro and in vivo. The effect of curcumin on replication of influenza A virus (IAV) was examined in human lung cancer cell line A549, as well as in a mouse model. Curcumin could inhibit IAV in vitro and alleviate the severity of the disease in the mouse after infection with IAV. The results also indicated that curcumin could trigger expression of Heme oxygenase-1 in vivo and attenuate IAV-induced injury to the lung tissue. Furthermore, curcumin could regulate immune response following IAV infection through inhibiting production of local inflammatory cytokines. In addition, curcumin was found to inhibit NF-kappaB signalling in macrophages, as well as the subsequent production of cytokines/chemokines responding to IAV infection, by enhancing IkappaBalpha and AMPK. Our current study supports the potential of curcumin as a promising treatment against IAV infection, whose effect may be mediated by regulating immune response to prevent injury to the lung tissue. Twit Text FOAVip Curcumin ameliorates severe influenza pneumonia via attenuating lung injury and regulating macrophage cytokines production ????Clin Exp Pharmacol Physiol http://www.kidney.de/pget.php?&tw=1&pmid=28853207 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28853207 #FOAvip English Wikipedia <ref>{{Cite pmid|28853207}}</ref> Curcumin ameliorates severe influenza pneumonia via attenuating lung injury and regulating macrophage cytokines production #MMPMID28853207 Han S; Xu J; Guo X; Huang M Clin Exp Pharmacol Physiol 2018[Jan]; 45 (1): 84-93 PMID28853207show ga Curcumin, an active phenolic agent extract from the Curcuma longa, exhibits excellent anti-cancer, anti-inflammation, and neuroprotective effects. We aimed to investigate the anti-influenza role of curcumin in vitro and in vivo. The effect of curcumin on replication of influenza A virus (IAV) was examined in human lung cancer cell line A549, as well as in a mouse model. Curcumin could inhibit IAV in vitro and alleviate the severity of the disease in the mouse after infection with IAV. The results also indicated that curcumin could trigger expression of Heme oxygenase-1 in vivo and attenuate IAV-induced injury to the lung tissue. Furthermore, curcumin could regulate immune response following IAV infection through inhibiting production of local inflammatory cytokines. In addition, curcumin was found to inhibit NF-kappaB signalling in macrophages, as well as the subsequent production of cytokines/chemokines responding to IAV infection, by enhancing IkappaBalpha and AMPK. Our current study supports the potential of curcumin as a promising treatment against IAV infection, whose effect may be mediated by regulating immune response to prevent injury to the lung tissue. |AMP-Activated Protein Kinases/metabolism[MESH] |Animals[MESH] |Curcumin/*pharmacology/therapeutic use[MESH] |Cytokines/*biosynthesis[MESH] |Enzyme Activation/drug effects[MESH] |Heme Oxygenase-1/metabolism[MESH] |I-kappa B Proteins/metabolism[MESH] |Influenza A Virus, H1N1 Subtype/drug effects/*physiology[MESH] |Lung/*drug effects/immunology/metabolism/virology[MESH] |Macrophages/*drug effects/metabolism[MESH] |Mice[MESH] |NF-kappa B/metabolism[MESH] |Pneumonia/*drug therapy/immunology/metabolism/*virology[MESH] |Up-Regulation/drug effects[MESH]Curcumin ameliorates severe influenza pneumonia via attenuating lung i(epmc).pdf DeepDyve Pubget Overpricing