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10.1073/pnas.1711950115 http://scihub22266oqcxt.onion/10.1073/pnas.1711950115 29295921!5776968!29295921     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29295921&cmd=llinks): Failed to open stream: HTTP request failed! 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Lymphocytes eject interferogenic mitochondrial DNA webs in response to CpG and non-CpG oligodeoxynucleotides of class C |pdf=|usr=}}{{29295921}} gab.com Text Lymphocytes eject interferogenic mitochondrial DNA webs in response to CpG and non-CpG oligodeoxynucleotides of class C JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=29295921 #FOAvip Circulating mitochondrial DNA (mtDNA) is receiving increasing attention as a danger-associated molecular pattern in conditions such as autoimmunity, cancer, and trauma. We report here that human lymphocytes [B cells, T cells, natural killer (NK) cells], monocytes, and neutrophils derived from healthy blood donors, as well as B cells from chronic lymphocytic leukemia patients, rapidly eject mtDNA as web filament structures upon recognition of CpG and non-CpG oligodeoxynucleotides of class C. The release was quenched by ZnCl(2), independent of cell death (apoptosis, necrosis, necroptosis, autophagy), and continued in the presence of TLR9 signaling inhibitors. B-cell mtDNA webs were distinct from neutrophil extracellular traps concerning structure, reactive oxygen species (ROS) dependence, and were devoid of antibacterial proteins. mtDNA webs acted as rapid (within minutes) messengers, priming antiviral type I IFN production. In summary, our findings point at a previously unrecognized role for lymphocytes in antimicrobial defense, utilizing mtDNA webs as signals in synergy with cytokines and natural antibodies, and cast light on the interplay between mitochondria and the immune system. Twit Text FOAVip Lymphocytes eject interferogenic mitochondrial DNA webs in response to CpG and non-CpG oligodeoxynucleotides of class C ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=29295921 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29295921 #FOAvip English Wikipedia <ref>{{Cite pmid|29295921}}</ref> Lymphocytes eject interferogenic mitochondrial DNA webs in response to CpG and non-CpG oligodeoxynucleotides of class C #MMPMID29295921 Ingelsson B; Soderberg D; Strid T; Soderberg A; Bergh AC; Loitto V; Lotfi K; Segelmark M; Spyrou G; Rosen A Proc Natl Acad Sci U S A 2018[Jan]; 115 (3): E478-E487 PMID29295921show ga Circulating mitochondrial DNA (mtDNA) is receiving increasing attention as a danger-associated molecular pattern in conditions such as autoimmunity, cancer, and trauma. We report here that human lymphocytes [B cells, T cells, natural killer (NK) cells], monocytes, and neutrophils derived from healthy blood donors, as well as B cells from chronic lymphocytic leukemia patients, rapidly eject mtDNA as web filament structures upon recognition of CpG and non-CpG oligodeoxynucleotides of class C. The release was quenched by ZnCl(2), independent of cell death (apoptosis, necrosis, necroptosis, autophagy), and continued in the presence of TLR9 signaling inhibitors. B-cell mtDNA webs were distinct from neutrophil extracellular traps concerning structure, reactive oxygen species (ROS) dependence, and were devoid of antibacterial proteins. mtDNA webs acted as rapid (within minutes) messengers, priming antiviral type I IFN production. In summary, our findings point at a previously unrecognized role for lymphocytes in antimicrobial defense, utilizing mtDNA webs as signals in synergy with cytokines and natural antibodies, and cast light on the interplay between mitochondria and the immune system. |Animals[MESH] |Cell Death[MESH] |Cells, Cultured[MESH] |CpG Islands/*physiology[MESH] |DNA, Mitochondrial/*metabolism[MESH] |DNA-Binding Proteins[MESH] |Humans[MESH] |Lymphocyte Activation[MESH] |Lymphocytes/*physiology[MESH] |Membrane Proteins[MESH] |Monocytes[MESH] |Neutrons[MESH] |Oligodeoxyribonucleotides/*classification[MESH] |Reactive Nitrogen Species[MESH] |Reactive Oxygen Species[MESH] |Receptors, Antigen, B-Cell[MESH]Lymphocytes eject interferogenic mitochondrial DNA webs in response to(epmc).pdf DeepDyve Pubget Overpricing