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10.1007/s10787-018-0457-1 http://scihub22266oqcxt.onion/10.1007/s10787-018-0457-1 29502306!ä!29502306 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29502306&cmd=llinks): Failed to open stream: HTTP request failed! 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Antiviral effects and mechanisms of Yinhuapinggan granule against H1N1 influenza virus infection in RAW264 7 cells |pdf=|usr=}}{{29502306}} gab.com Text Antiviral effects and mechanisms of Yinhuapinggan granule against H1N1 influenza virus infection in RAW264 7 cells JO: Inflammopharmacology http://www.kidney.de/pget.php?&tw=1&pmid=29502306 #FOAvip Yinhuapinggan granule (YHPG), a modified prescription based on Ma-Huang-Tang (MHT), is used in traditional Chinese medicine (TCM) to treat influenza, cough, and viral pneumonia. In this study, we investigated the antiviral effects of YHPG by means of pre-, post-, and co-treatment, and its underlying mechanisms on regulating the levels of inflammatory-related cytokines, modulating the mRNA expressions of interferon-stimulated genes in influenza virus-infected murine macrophage cells (RAW264.7), and evaluating the protein expressions of key effectors in the Type I IFN and pattern recognition receptor (PRRs) signaling pathways. The results showed that YHPG markedly inhibited influenza virus (IFV) replication in pre-, post- and co-treatment assay, especially in post-treatment assay. Antiviral mechanisms studies revealed that YHPG (500 and 250 mug/mL) significantly up-regulated levels of IFN-beta, IFN-stimulated genes (Mx-1, ISG-15 and ISG-56) compared with the IFV control group, while the levels of IL-6 and TNF-alpha were significantly down-regulated. Furthermore, western blot analysis results revealed that the protein expressions of the phosphorylated forms of TBK1, IRF3, ERK1/2, P38 MAPK and NF-kappaB p65 were significantly down-regulated in RAW264.7 cells with the YHPG (500 and 250 mug/mL) treatment, while the expression of the phosphorylated form of STAT1 was significantly enhanced. Based on these results, YHPG had antiviral effects in IFV-infected RAW264.7 cells, which might be associated with regulation of the inflammatory cytokines production, evaluation of the levels of IFN-stimulated genes, and modulation of the protein expressions of key effectors in the Type I IFN and PRRs signaling pathways. Twit Text FOAVip Antiviral effects and mechanisms of Yinhuapinggan granule against H1N1 influenza virus infection in RAW264 7 cells ????Inflammopharmacology http://www.kidney.de/pget.php?&tw=1&pmid=29502306 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29502306 #FOAvip English Wikipedia <ref>{{Cite pmid|29502306}}</ref> Antiviral effects and mechanisms of Yinhuapinggan granule against H1N1 influenza virus infection in RAW264 7 cells #MMPMID29502306 Du HX; Zhou HF; Wan HF; Yang JH; Lu YY; He Y; Wan HT Inflammopharmacology 2018[Dec]; 26 (6): 1455-1467 PMID29502306show ga Yinhuapinggan granule (YHPG), a modified prescription based on Ma-Huang-Tang (MHT), is used in traditional Chinese medicine (TCM) to treat influenza, cough, and viral pneumonia. In this study, we investigated the antiviral effects of YHPG by means of pre-, post-, and co-treatment, and its underlying mechanisms on regulating the levels of inflammatory-related cytokines, modulating the mRNA expressions of interferon-stimulated genes in influenza virus-infected murine macrophage cells (RAW264.7), and evaluating the protein expressions of key effectors in the Type I IFN and pattern recognition receptor (PRRs) signaling pathways. The results showed that YHPG markedly inhibited influenza virus (IFV) replication in pre-, post- and co-treatment assay, especially in post-treatment assay. Antiviral mechanisms studies revealed that YHPG (500 and 250 mug/mL) significantly up-regulated levels of IFN-beta, IFN-stimulated genes (Mx-1, ISG-15 and ISG-56) compared with the IFV control group, while the levels of IL-6 and TNF-alpha were significantly down-regulated. Furthermore, western blot analysis results revealed that the protein expressions of the phosphorylated forms of TBK1, IRF3, ERK1/2, P38 MAPK and NF-kappaB p65 were significantly down-regulated in RAW264.7 cells with the YHPG (500 and 250 mug/mL) treatment, while the expression of the phosphorylated form of STAT1 was significantly enhanced. Based on these results, YHPG had antiviral effects in IFV-infected RAW264.7 cells, which might be associated with regulation of the inflammatory cytokines production, evaluation of the levels of IFN-stimulated genes, and modulation of the protein expressions of key effectors in the Type I IFN and PRRs signaling pathways. |Animals[MESH] |Antiviral Agents/*pharmacology[MESH] |Cell Survival/drug effects[MESH] |Cytokines/metabolism[MESH] |Drugs, Chinese Herbal/*pharmacology[MESH] |Gene Expression Regulation, Viral/drug effects[MESH] |Humans[MESH] |Influenza A Virus, H1N1 Subtype/*drug effects[MESH] |Influenza, Human/drug therapy/virology[MESH] |Interferons/pharmacology[MESH] |Mice[MESH] |RAW 264.7 Cells[MESH] |RNA, Viral/antagonists & inhibitors/biosynthesis[MESH] |Signal Transduction/drug effects[MESH]Antiviral effects and mechanisms of Yinhuapinggan granule against H1N1(epmc).pdf DeepDyve Pubget Overpricing