Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1152/ajprenal.1985.248.4.F487 http://scihub22266oqcxt.onion/10.1152/ajprenal.1985.248.4.F487 2984945!ä!2984945 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\2984945.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Am+J+Physiol 1985 ; 248 (4 Pt 2): F487-91 Nephropedia Template TP {{tp|p=2984945|t=1985. Glucocorticoid effects on Na-K-ATPase in rabbit nephron segments |pdf=|usr=}}{{2984945}} gab.com Text Glucocorticoid effects on Na-K-ATPase in rabbit nephron segments JO: Am J Physiol http://www.kidney.de/pget.php?&tw=1&pmid=2984945 #FOAvip We determined the effect of dexamethasone on Na-K-ATPase activity in six nephron segments of the adrenalectomized rabbit. Treatment consisted of 1.4 micrograms dexamethasone X 100 g body wt-1 X day-1 for 7 days prior to the study of the nephron segments. Enzyme activity was determined in individual nephron segments by a microfluorometric assay. There was 40-50% less activity of Na-K-ATPase in the S1 portion of the proximal convoluted tubule (PCT, S1), the medullary thick ascending limb (MTAL), and the distal convoluted tubule (DCT) of adrenalectomized rabbits compared with that of control (sham-operated) animals. There was no significant difference in the enzyme activity in proximal straight tubules (PST, S2 and S3) and cortical thick ascending limb (CTAL) of adrenalectomized and control animals. Dexamethasone treatment produced a dexamethasone concentration of 5 +/- 0.8 nM in the plasma and increased Na-K-ATPase activity in PCT (S1), MTAL, and DCT of the adrenalectomized animals to the control levels without significantly affecting the enzyme activity in the PST (S2, S3) or CTAL. The concentration of dexamethasone in the plasma was such that the hormone should bind mainly to dexamethasone receptors (Kd = 5 nM) and very little to aldosterone receptors (Kd greater than 60 nM). Thus, glucocorticoids probably stimulate Na-K-ATPase in PCT, MTAL, and DCT through glucocorticoid (Type II) receptors and not through mineralocorticoid (Type I) receptors. Twit Text FOAVip Glucocorticoid effects on Na-K-ATPase in rabbit nephron segments ????Am J Physiol http://www.kidney.de/pget.php?&tw=1&pmid=2984945 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=2984945 #FOAvip English Wikipedia <ref>{{Cite pmid|2984945}}</ref> Glucocorticoid effects on Na-K-ATPase in rabbit nephron segments #MMPMID2984945 Garg LC; Narang N; Wingo CS Am J Physiol 1985[Apr]; 248 (4 Pt 2): F487-91 PMID2984945show ga We determined the effect of dexamethasone on Na-K-ATPase activity in six nephron segments of the adrenalectomized rabbit. Treatment consisted of 1.4 micrograms dexamethasone X 100 g body wt-1 X day-1 for 7 days prior to the study of the nephron segments. Enzyme activity was determined in individual nephron segments by a microfluorometric assay. There was 40-50% less activity of Na-K-ATPase in the S1 portion of the proximal convoluted tubule (PCT, S1), the medullary thick ascending limb (MTAL), and the distal convoluted tubule (DCT) of adrenalectomized rabbits compared with that of control (sham-operated) animals. There was no significant difference in the enzyme activity in proximal straight tubules (PST, S2 and S3) and cortical thick ascending limb (CTAL) of adrenalectomized and control animals. Dexamethasone treatment produced a dexamethasone concentration of 5 +/- 0.8 nM in the plasma and increased Na-K-ATPase activity in PCT (S1), MTAL, and DCT of the adrenalectomized animals to the control levels without significantly affecting the enzyme activity in the PST (S2, S3) or CTAL. The concentration of dexamethasone in the plasma was such that the hormone should bind mainly to dexamethasone receptors (Kd = 5 nM) and very little to aldosterone receptors (Kd greater than 60 nM). Thus, glucocorticoids probably stimulate Na-K-ATPase in PCT, MTAL, and DCT through glucocorticoid (Type II) receptors and not through mineralocorticoid (Type I) receptors. |Adenosine Triphosphatases/metabolism[MESH] |Adrenalectomy[MESH] |Animals[MESH] |Body Weight[MESH] |Ca(2+) Mg(2+)-ATPase[MESH] |Dexamethasone/blood/*pharmacology[MESH] |Diuresis[MESH] |Kidney/anatomy & histology[MESH] |Male[MESH] |Nephrons/*enzymology[MESH] |Organ Size[MESH] |Potassium/blood[MESH] |Rabbits[MESH] |Sodium-Potassium-Exchanging ATPase/*metabolism[MESH] |Sodium/blood[MESH]Glucocorticoid effects on Na-K-ATPase in rabbit nephron segments (epmc).pdf DeepDyve Pubget Overpricing