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Inflammatory consequences of inherited disorders affecting neutrophil function #MMPMID30898864
Dinauer MC
Blood 2019[May]; 133 (20): 2130-2139 PMID30898864show ga
Primary immunodeficiencies affecting the function of neutrophils and other phagocytic leukocytes are notable for an increased susceptibility to bacterial and fungal infections as a result of impaired leukocyte recruitment, ingestion, and/or killing of microbes. The underlying molecular defects can also impact other innate immune responses to infectious and inflammatory stimuli, leading to inflammatory and autoimmune complications that are not always directly related to infection. This review will provide an update on congenital disorders affecting neutrophil function in which a combination of host defense and inflammatory complications are prominent, including nicotinamide dinucleotide phosphate oxidase defects in chronic granulomatous disease and beta2 integrin defects in leukocyte adhesion deficiency.