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10.1080/03008207.2019.1593392 http://scihub22266oqcxt.onion/10.1080/03008207.2019.1593392 30909748!ä!30909748 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=30909748&cmd=llinks): Failed to open stream: HTTP request failed! 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Magnesium lithospermate B inhibits titanium particles-induced osteoclast formation by c-fos and inhibiting NFATc1 expression |pdf=|usr=}}{{30909748}} gab.com Text Magnesium lithospermate B inhibits titanium particles-induced osteoclast formation by c-fos and inhibiting NFATc1 expression JO: Connect Tissue Res http://www.kidney.de/pget.php?&tw=1&pmid=30909748 #FOAvip Purpose: Titanium particle-induced osteolysis is one of the important causes of aseptic loosening of artificial joints. Previous studies have shown the potential of natural compounds in preventing Ti particle-induced bone resorption. In this study, we observed the effects of magnesium lithospermate B (MLB) on titanium particle-induced osteoclast activity in vitro. Materials and Methods: RAW264.7 cells were treated with titanium particles (0.1 mg/mL) in the presence or absence of MLB (200 nmol/L). We evaluated the osteoclast formation, bone pits formation and tartrate-resistant acid phosphatase 5b (Tracp5b) levels. Reverse transcription polymerase chain reaction (RT-PCR) and Western blot were used to evaluate osteoclast differentiation-related genes (TRAF6, NFATc1, and c-fos) and protein expression. Results: The number of osteoclasts, pit formation and Tracp5b levels were all the group treated with titanium particles compared to the control group (all p < 0.05). Titanium particles also promoted the expression of the TRAF6, NFATc1 and c-fos genes and protein expression. MLB significantly abolished the titanium particle-enhanced osteoclast and pits formation, and Traf6, NFATc1, and c-fos expression. Conclusions: Our data demonstrated that MLB can suppress titanium-induced osteoclast activity via inhibiting c-fos and NFATc1 expression. Twit Text FOAVip Magnesium lithospermate B inhibits titanium particles-induced osteoclast formation by c-fos and inhibiting NFATc1 expression ????Connect Tissue Res http://www.kidney.de/pget.php?&tw=1&pmid=30909748 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30909748 #FOAvip English Wikipedia <ref>{{Cite pmid|30909748}}</ref> Magnesium lithospermate B inhibits titanium particles-induced osteoclast formation by c-fos and inhibiting NFATc1 expression #MMPMID30909748 Miao W; Gao H; Hou X Connect Tissue Res 2019[Sep]; 60 (5): 487-494 PMID30909748show ga Purpose: Titanium particle-induced osteolysis is one of the important causes of aseptic loosening of artificial joints. Previous studies have shown the potential of natural compounds in preventing Ti particle-induced bone resorption. In this study, we observed the effects of magnesium lithospermate B (MLB) on titanium particle-induced osteoclast activity in vitro. Materials and Methods: RAW264.7 cells were treated with titanium particles (0.1 mg/mL) in the presence or absence of MLB (200 nmol/L). We evaluated the osteoclast formation, bone pits formation and tartrate-resistant acid phosphatase 5b (Tracp5b) levels. Reverse transcription polymerase chain reaction (RT-PCR) and Western blot were used to evaluate osteoclast differentiation-related genes (TRAF6, NFATc1, and c-fos) and protein expression. Results: The number of osteoclasts, pit formation and Tracp5b levels were all the group treated with titanium particles compared to the control group (all p < 0.05). Titanium particles also promoted the expression of the TRAF6, NFATc1 and c-fos genes and protein expression. MLB significantly abolished the titanium particle-enhanced osteoclast and pits formation, and Traf6, NFATc1, and c-fos expression. Conclusions: Our data demonstrated that MLB can suppress titanium-induced osteoclast activity via inhibiting c-fos and NFATc1 expression. |Animals[MESH] |Cell Survival/drug effects[MESH] |Drugs, Chinese Herbal/*pharmacology[MESH] |Mice[MESH] |NFATC Transcription Factors/genetics/*metabolism[MESH] |Osteoclasts/drug effects/*metabolism[MESH] |Osteogenesis/drug effects[MESH] |Proto-Oncogene Proteins c-fos/genetics/*metabolism[MESH] |RANK Ligand/pharmacology[MESH] |RAW 264.7 Cells[MESH] |RNA, Messenger/genetics/metabolism[MESH] |Tartrate-Resistant Acid Phosphatase/genetics/metabolism[MESH]Magnesium lithospermate B inhibits titanium particles-induced osteocla(epmc).pdf DeepDyve Pubget Overpricing