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10.1084/jem.20190185 http://scihub22266oqcxt.onion/10.1084/jem.20190185 30962246!6504211!30962246     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=30962246&cmd=llinks): Failed to open stream: HTTP request failed! 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Longitudinal profiling of human blood transcriptome in healthy and lupus pregnancy |pdf=|usr=}}{{30962246}} gab.com Text Longitudinal profiling of human blood transcriptome in healthy and lupus pregnancy JO: J Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=30962246 #FOAvip Systemic lupus erythematosus carries an increased risk of pregnancy complications, including preeclampsia and fetal adverse outcomes. To identify the underlying molecular mechanisms, we longitudinally profiled the blood transcriptome of 92 lupus patients and 43 healthy women during pregnancy and postpartum and performed multicolor flow cytometry in a subset of them. We also profiled 25 healthy women undergoing assisted reproductive technology to monitor transcriptional changes around embryo implantation. Sustained down-regulation of multiple immune signatures, including interferon and plasma cells, was observed during healthy pregnancy. These changes appeared early after embryo implantation and were mirrored in uncomplicated lupus pregnancies. Patients with preeclampsia displayed early up-regulation of neutrophil signatures that correlated with expansion of immature neutrophils. Lupus pregnancies with fetal complications carried the highest interferon and plasma cell signatures as well as activated CD4(+) T cell counts. Thus, blood immunomonitoring reveals that both healthy and uncomplicated lupus pregnancies exhibit early and sustained transcriptional modulation of lupus-related signatures, and a lack thereof associates with adverse outcomes. Twit Text FOAVip Longitudinal profiling of human blood transcriptome in healthy and lupus pregnancy ????J Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=30962246 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30962246 #FOAvip English Wikipedia <ref>{{Cite pmid|30962246}}</ref> Longitudinal profiling of human blood transcriptome in healthy and lupus pregnancy #MMPMID30962246 Hong S; Banchereau R; Maslow BL; Guerra MM; Cardenas J; Baisch J; Branch DW; Porter TF; Sawitzke A; Laskin CA; Buyon JP; Merrill J; Sammaritano LR; Petri M; Gatewood E; Cepika AM; Ohouo M; Obermoser G; Anguiano E; Kim TW; Nulsen J; Nehar-Belaid D; Blankenship D; Turner J; Banchereau J; Salmon JE; Pascual V J Exp Med 2019[May]; 216 (5): 1154-1169 PMID30962246show ga Systemic lupus erythematosus carries an increased risk of pregnancy complications, including preeclampsia and fetal adverse outcomes. To identify the underlying molecular mechanisms, we longitudinally profiled the blood transcriptome of 92 lupus patients and 43 healthy women during pregnancy and postpartum and performed multicolor flow cytometry in a subset of them. We also profiled 25 healthy women undergoing assisted reproductive technology to monitor transcriptional changes around embryo implantation. Sustained down-regulation of multiple immune signatures, including interferon and plasma cells, was observed during healthy pregnancy. These changes appeared early after embryo implantation and were mirrored in uncomplicated lupus pregnancies. Patients with preeclampsia displayed early up-regulation of neutrophil signatures that correlated with expansion of immature neutrophils. Lupus pregnancies with fetal complications carried the highest interferon and plasma cell signatures as well as activated CD4(+) T cell counts. Thus, blood immunomonitoring reveals that both healthy and uncomplicated lupus pregnancies exhibit early and sustained transcriptional modulation of lupus-related signatures, and a lack thereof associates with adverse outcomes. |*Transcriptome[MESH] |Adult[MESH] |Biomarkers[MESH] |Embryo Implantation/genetics[MESH] |Female[MESH] |Humans[MESH] |Longitudinal Studies[MESH] |Lupus Erythematosus, Systemic/*blood/*genetics[MESH] |Pre-Eclampsia/genetics[MESH] |Pregnancy[MESH] |Pregnancy Complications/*blood/*genetics[MESH] |Prospective Studies[MESH]Longitudinal profiling of human blood transcriptome in healthy and lup(epmc).pdf DeepDyve Pubget Overpricing