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10.3389/fimmu.2019.00325 http://scihub22266oqcxt.onion/10.3389/fimmu.2019.00325 30984161!6449421!30984161     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=30984161&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\30984161.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Front+Immunol 2019 ; 10 (ä): 325 Nephropedia Template TP {{tp|p=30984161|t=2019. Regulating IRFs in IFN Driven Disease |pdf=|usr=}}{{30984161}} gab.com Text Regulating IRFs in IFN Driven Disease JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=30984161 #FOAvip The Interferon regulatory factors (IRFs) are a family of transcription factors that play pivotal roles in many aspects of the immune response, including immune cell development and differentiation and regulating responses to pathogens. Three family members, IRF3, IRF5, and IRF7, are critical to production of type I interferons downstream of pathogen recognition receptors that detect viral RNA and DNA. A fourth family member, IRF9, regulates interferon-driven gene expression. In addition, IRF4, IRF8, and IRF5 regulate myeloid cell development and phenotype, thus playing important roles in regulating inflammatory responses. Thus, understanding how their levels and activity is regulated is of critical importance given that perturbations in either can result in dysregulated immune responses and potential autoimmune disease. This review will focus the role of IRF family members in regulating type I IFN production and responses and myeloid cell development or differentiation, with particular emphasis on how regulation of their levels and activity by ubiquitination and microRNAs may impact autoimmune disease. Twit Text FOAVip Regulating IRFs in IFN Driven Disease ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=30984161 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30984161 #FOAvip English Wikipedia <ref>{{Cite pmid|30984161}}</ref> Regulating IRFs in IFN Driven Disease #MMPMID30984161 Jefferies CA Front Immunol 2019[]; 10 (ä): 325 PMID30984161show ga The Interferon regulatory factors (IRFs) are a family of transcription factors that play pivotal roles in many aspects of the immune response, including immune cell development and differentiation and regulating responses to pathogens. Three family members, IRF3, IRF5, and IRF7, are critical to production of type I interferons downstream of pathogen recognition receptors that detect viral RNA and DNA. A fourth family member, IRF9, regulates interferon-driven gene expression. In addition, IRF4, IRF8, and IRF5 regulate myeloid cell development and phenotype, thus playing important roles in regulating inflammatory responses. Thus, understanding how their levels and activity is regulated is of critical importance given that perturbations in either can result in dysregulated immune responses and potential autoimmune disease. This review will focus the role of IRF family members in regulating type I IFN production and responses and myeloid cell development or differentiation, with particular emphasis on how regulation of their levels and activity by ubiquitination and microRNAs may impact autoimmune disease. |Animals[MESH] |DNA, Viral/immunology[MESH] |Gene Expression Regulation/*immunology[MESH] |Humans[MESH] |Interferon Regulatory Factors/*immunology[MESH] |Interferon Type I/*immunology[MESH] |Myeloid Cells/*immunology[MESH] |RNA, Viral/immunology[MESH]Regulating IRFs in IFN Driven Disease (epmc).pdf DeepDyve Pubget Overpricing