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10.1016/j.biopha.2019.108954 http://scihub22266oqcxt.onion/10.1016/j.biopha.2019.108954 31108352!ä!31108352 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=31108352&cmd=llinks): Failed to open stream: HTTP request failed! 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The therapeutic impact of entresto on protecting against cardiorenal syndrome-associated renal damage in rats on high protein diet |pdf=|usr=}}{{31108352}} gab.com Text The therapeutic impact of entresto on protecting against cardiorenal syndrome-associated renal damage in rats on high protein diet JO: Biomed Pharmacother http://www.kidney.de/pget.php?&tw=1&pmid=31108352 #FOAvip BACKGROUND: This study tested the hypothesis that Entresto could safely and effectively preserve heart and kidney function in rats with cardiorenal syndrome (CRS) induced by 5/6 nephrectomy and intra-peritoneal doxorubicin administration (accumulated dosage up to 7.5 mg/kg) together with daily high-protein-diet (H(PD)). METHODS AND RESULTS: Adult male Sprague-Dawley rats (n = 24) were equally categorized into Group 1 (sham-operated control + H(PD)), Group 2 (CRS + H(PD)) and Group 3 [CRS + H(PD) + Entresto (100 mg/kg/day orally) since Day 14 after CRS induction] and euthanized by Day 63 after CRS induction. By Day 63, circulatory BUN and creatinine levels and ratios of urine protein to creatinine were significantly higher in Group 2 than those in Groups 1 and 3, and significantly higher in Group 3 than in Group 1, whereas left-ventricular ejection fraction and kidney weight showed an opposite pattern among all groups (all p < 0.001). Microscopically, fibrosis area and intensity of oxidative stress (i.e., DCFDA stain) in kidney/heart tissues exhibited a pattern identical to that of creatinine level among all groups (all p < 0.0001). Kidney injury score and protein expressions of autophagy (i.e., beclin-1/Atg-5/protein ratio of LC3-BII/LC3-BI), fibrosis (Smad3/TGF-ss), apoptosis (mitochondrial-Bax/capase2/3/9), oxidative-stress (NOX-4/oxidized protein/xanthine-oxidase/catalase), membranous p47phox phosphorylation and mitochondrial-damage biomarker (cytosolic-cytochrome-C) were higher in Group 2 than those in Groups 1 and 3, and significantly higher in Group 3 than in Group 1, while protein expressions of anti-apoptosis (Bcl-2/Bcl-XL) and mitochondrial integrity (mitochondrial-cytochrome-C) markers displayed an opposite pattern among all groups in kidney tissues (all p < 0.0001). CONCLUSION: Oral administration of entresto was safe and could offer protection against CRS-induced heart and kidney damage. Twit Text FOAVip The therapeutic impact of entresto on protecting against cardiorenal syndrome-associated renal damage in rats on high protein diet ????Biomed Pharmacother http://www.kidney.de/pget.php?&tw=1&pmid=31108352 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=31108352 #FOAvip English Wikipedia <ref>{{Cite pmid|31108352}}</ref> The therapeutic impact of entresto on protecting against cardiorenal syndrome-associated renal damage in rats on high protein diet #MMPMID31108352 Yang CC; Chen YT; Chen CH; Li YC; Shao PL; Huang TH; Chen YL; Sun CK; Yip HK Biomed Pharmacother 2019[Aug]; 116 (ä): 108954 PMID31108352show ga BACKGROUND: This study tested the hypothesis that Entresto could safely and effectively preserve heart and kidney function in rats with cardiorenal syndrome (CRS) induced by 5/6 nephrectomy and intra-peritoneal doxorubicin administration (accumulated dosage up to 7.5 mg/kg) together with daily high-protein-diet (H(PD)). METHODS AND RESULTS: Adult male Sprague-Dawley rats (n = 24) were equally categorized into Group 1 (sham-operated control + H(PD)), Group 2 (CRS + H(PD)) and Group 3 [CRS + H(PD) + Entresto (100 mg/kg/day orally) since Day 14 after CRS induction] and euthanized by Day 63 after CRS induction. By Day 63, circulatory BUN and creatinine levels and ratios of urine protein to creatinine were significantly higher in Group 2 than those in Groups 1 and 3, and significantly higher in Group 3 than in Group 1, whereas left-ventricular ejection fraction and kidney weight showed an opposite pattern among all groups (all p < 0.001). Microscopically, fibrosis area and intensity of oxidative stress (i.e., DCFDA stain) in kidney/heart tissues exhibited a pattern identical to that of creatinine level among all groups (all p < 0.0001). Kidney injury score and protein expressions of autophagy (i.e., beclin-1/Atg-5/protein ratio of LC3-BII/LC3-BI), fibrosis (Smad3/TGF-ss), apoptosis (mitochondrial-Bax/capase2/3/9), oxidative-stress (NOX-4/oxidized protein/xanthine-oxidase/catalase), membranous p47phox phosphorylation and mitochondrial-damage biomarker (cytosolic-cytochrome-C) were higher in Group 2 than those in Groups 1 and 3, and significantly higher in Group 3 than in Group 1, while protein expressions of anti-apoptosis (Bcl-2/Bcl-XL) and mitochondrial integrity (mitochondrial-cytochrome-C) markers displayed an opposite pattern among all groups in kidney tissues (all p < 0.0001). CONCLUSION: Oral administration of entresto was safe and could offer protection against CRS-induced heart and kidney damage. |*Diet, High-Protein[MESH] |Aminobutyrates/pharmacology/*therapeutic use[MESH] |Animals[MESH] |Apoptosis/drug effects[MESH] |Autophagy/drug effects[MESH] |Biomarkers/metabolism[MESH] |Biphenyl Compounds[MESH] |Blood Urea Nitrogen[MESH] |Cardio-Renal Syndrome/blood/*drug therapy/genetics/physiopathology[MESH] |Creatinine/blood[MESH] |Drug Combinations[MESH] |Fibrosis[MESH] |Gene Expression Regulation/drug effects[MESH] |Kidney/*pathology[MESH] |Male[MESH] |Mitochondria/drug effects/metabolism[MESH] |Myocardium/pathology[MESH] |NADPH Oxidases/metabolism[MESH] |Oxidative Stress/drug effects[MESH] |Rats, Sprague-Dawley[MESH] |Reactive Oxygen Species/metabolism[MESH] |Receptor, Angiotensin, Type 2/metabolism[MESH] |Tetrazoles/pharmacology/*therapeutic use[MESH]The therapeutic impact of entresto on protecting against cardiorenal (epmc).pdf DeepDyve Pubget Overpricing