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10.1210/jc.2019-00706 http://scihub22266oqcxt.onion/10.1210/jc.2019-00706 31162549!ä!31162549 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\31162549.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Clin+Endocrinol+Metab 2019 ; 104 (10): 4253-4263 Nephropedia Template TP {{tp|p=31162549|t=2019. The Effects of Dapagliflozin on Systemic and Renal Vascular Function Display an Epigenetic Signature |pdf=|usr=}}{{31162549}} gab.com Text The Effects of Dapagliflozin on Systemic and Renal Vascular Function Display an Epigenetic Signature JO: J Clin Endocrinol Metab http://www.kidney.de/pget.php?&tw=1&pmid=31162549 #FOAvip CONTEXT: Mechanisms mediating the cardiovascular and renal protection exerted by SGLT2 inhibitors are still partially unknown. We investigated whether dapagliflozin modulates systemic and renal vascular function and structure, and induces epigenetic modifications. SUBJECTS AND METHODS: Forty hypertensive patients with type 2 diabetes were randomly assigned to 4-week treatment with dapagliflozin 10 mg or hydrochlorothiazide (HCT) 12.5 mg. Routine analyses; plasma renin activity; aldosterone, catecholamine, and 24-hour urinary electrolyte levels; flow-mediated dilation (FMD) of the brachial artery; carotid-femoral pulse-wave velocity (PWV); augmentation index; and resistive index and dynamic renal resistive index (DRIN) were measured at baseline and after treatment. Circulating miRNAs (miRs) related to heart failure (miR30e-5p, miR199a-3p), endothelial dysfunction (miR27b and miR200b), and renal function (miR130b-3p, miR21-5p) were assessed and related to the effects of treatments. RESULTS: Dapagliflozin and HCT marginally lowered blood pressure. Fasting glucose was lowered, whereas 24-hour diuresis, glycosuria, and osmolar clearance were increased by dapagliflozin (P < 0.001 for all), without affecting sodium excretion and glomerular filtration rate. Magnesium levels significantly increased after dapagliflozin treatment (P = 0.02). Neither dapagliflozin nor HCT modified FMD or PWV. DRIN did not vary in the dapagliflozin group, whereas it increased in the HCT group (P = 0.047 for time by treatment interaction). Both treatments induced variations in the expression of some miRs; dapagliflozin, but not HCT, significantly up-regulated miR30e-5p and downregulated miR199a-3p. CONCLUSION: A putative epigenetic regulation of the protecting cardiovascular effect exerted by SGLT2 inhibitors was found. Dapagliflozin might exert nephroprotection by preserving renal vasodilating capacity. Twit Text FOAVip The Effects of Dapagliflozin on Systemic and Renal Vascular Function Display an Epigenetic Signature ????J Clin Endocrinol Metab http://www.kidney.de/pget.php?&tw=1&pmid=31162549 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=31162549 #FOAvip English Wikipedia <ref>{{Cite pmid|31162549}}</ref> The Effects of Dapagliflozin on Systemic and Renal Vascular Function Display an Epigenetic Signature #MMPMID31162549 Solini A; Seghieri M; Giannini L; Biancalana E; Parolini F; Rossi C; Dardano A; Taddei S; Ghiadoni L; Bruno RM J Clin Endocrinol Metab 2019[Oct]; 104 (10): 4253-4263 PMID31162549show ga CONTEXT: Mechanisms mediating the cardiovascular and renal protection exerted by SGLT2 inhibitors are still partially unknown. We investigated whether dapagliflozin modulates systemic and renal vascular function and structure, and induces epigenetic modifications. SUBJECTS AND METHODS: Forty hypertensive patients with type 2 diabetes were randomly assigned to 4-week treatment with dapagliflozin 10 mg or hydrochlorothiazide (HCT) 12.5 mg. Routine analyses; plasma renin activity; aldosterone, catecholamine, and 24-hour urinary electrolyte levels; flow-mediated dilation (FMD) of the brachial artery; carotid-femoral pulse-wave velocity (PWV); augmentation index; and resistive index and dynamic renal resistive index (DRIN) were measured at baseline and after treatment. Circulating miRNAs (miRs) related to heart failure (miR30e-5p, miR199a-3p), endothelial dysfunction (miR27b and miR200b), and renal function (miR130b-3p, miR21-5p) were assessed and related to the effects of treatments. RESULTS: Dapagliflozin and HCT marginally lowered blood pressure. Fasting glucose was lowered, whereas 24-hour diuresis, glycosuria, and osmolar clearance were increased by dapagliflozin (P < 0.001 for all), without affecting sodium excretion and glomerular filtration rate. Magnesium levels significantly increased after dapagliflozin treatment (P = 0.02). Neither dapagliflozin nor HCT modified FMD or PWV. DRIN did not vary in the dapagliflozin group, whereas it increased in the HCT group (P = 0.047 for time by treatment interaction). Both treatments induced variations in the expression of some miRs; dapagliflozin, but not HCT, significantly up-regulated miR30e-5p and downregulated miR199a-3p. CONCLUSION: A putative epigenetic regulation of the protecting cardiovascular effect exerted by SGLT2 inhibitors was found. Dapagliflozin might exert nephroprotection by preserving renal vasodilating capacity. |Adult[MESH] |Aged[MESH] |Analysis of Variance[MESH] |Benzhydryl Compounds/*administration & dosage[MESH] |Blood Glucose/drug effects[MESH] |Diabetes Mellitus, Type 2/complications/diagnosis/*drug therapy[MESH] |Epigenesis, Genetic/*drug effects[MESH] |Female[MESH] |Glomerular Filtration Rate/drug effects[MESH] |Glucosides/*administration & dosage[MESH] |Hospitals, University[MESH] |Humans[MESH] |Hydrochlorothiazide/*administration & dosage[MESH] |Hypertension/complications/diagnosis/*drug therapy[MESH] |Italy[MESH] |Male[MESH] |MicroRNAs/drug effects/*genetics[MESH] |Middle Aged[MESH] |Prognosis[MESH] |Renal Circulation/drug effects[MESH] |Sodium-Glucose Transporter 2 Inhibitors/administration & dosage[MESH] |Statistics, Nonparametric[MESH] |Treatment Outcome[MESH]The Effects of Dapagliflozin on Systemic and Renal Vascular Function D(epmc).pdf DeepDyve Pubget Overpricing