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10.3390/cells8070716 http://scihub22266oqcxt.onion/10.3390/cells8070716 31337034!6679024!31337034     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=31337034&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\31337034.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cells 2019 ; 8 (7): ä Nephropedia Template TP {{tp|p=31337034|t=2019. Novel Aspects of Extracellular Vesicles as Mediators of Cancer-Associated Thrombosis |pdf=|usr=}}{{31337034}} gab.com Text Novel Aspects of Extracellular Vesicles as Mediators of Cancer-Associated Thrombosis JO: Cells http://www.kidney.de/pget.php?&tw=1&pmid=31337034 #FOAvip The establishment of prothrombotic states during cancer progression is well reported but the precise mechanisms underlying this process remain elusive. A number of studies have implicated the presence of the clotting initiator protein, tissue factor (TF), in circulating tumor-derived extracellular vesicles (EVs) with thrombotic manifestations in certain cancer types. Tumor cells, as well as tumor-derived EVs, may activate and promote platelet aggregation by TF-dependent and independent pathways. Cancer cells and their secreted EVs may also facilitate the formation of neutrophil extracellular traps (NETs), which may contribute to thrombus development. Alternatively, the presence of polyphosphate (polyP) in tumor-derived EVs may promote thrombosis through a TF-independent route. We conclude that the contribution of EVs to cancer coagulopathy is quite complex, in which one or more mechanisms may take place in a certain cancer type. In this context, strategies that could attenuate the crosstalk between the proposed pro-hemostatic routes could potentially reduce cancer-associated thrombosis. Twit Text FOAVip Novel Aspects of Extracellular Vesicles as Mediators of Cancer-Associated Thrombosis ????Cells http://www.kidney.de/pget.php?&tw=1&pmid=31337034 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=31337034 #FOAvip English Wikipedia <ref>{{Cite pmid|31337034}}</ref> Novel Aspects of Extracellular Vesicles as Mediators of Cancer-Associated Thrombosis #MMPMID31337034 Almeida VH; Rondon AMR; Gomes T; Monteiro RQ Cells 2019[Jul]; 8 (7): ä PMID31337034show ga The establishment of prothrombotic states during cancer progression is well reported but the precise mechanisms underlying this process remain elusive. A number of studies have implicated the presence of the clotting initiator protein, tissue factor (TF), in circulating tumor-derived extracellular vesicles (EVs) with thrombotic manifestations in certain cancer types. Tumor cells, as well as tumor-derived EVs, may activate and promote platelet aggregation by TF-dependent and independent pathways. Cancer cells and their secreted EVs may also facilitate the formation of neutrophil extracellular traps (NETs), which may contribute to thrombus development. Alternatively, the presence of polyphosphate (polyP) in tumor-derived EVs may promote thrombosis through a TF-independent route. We conclude that the contribution of EVs to cancer coagulopathy is quite complex, in which one or more mechanisms may take place in a certain cancer type. In this context, strategies that could attenuate the crosstalk between the proposed pro-hemostatic routes could potentially reduce cancer-associated thrombosis. |*Neoplasms/complications/pathology[MESH] |*Platelet Aggregation[MESH] |*Thrombosis/complications/metabolism[MESH] |Animals[MESH] |Cell Line, Tumor[MESH] |Extracellular Traps/*metabolism[MESH] |Extracellular Vesicles/*metabolism[MESH] |Humans[MESH] |Neutrophils/cytology/metabolism[MESH] |Polyphosphates/metabolism[MESH]Novel Aspects of Extracellular Vesicles as Mediators of Cancer-Associa(epmc).pdf DeepDyve Pubget Overpricing