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10.1016/j.biopha.2019.109316 http://scihub22266oqcxt.onion/10.1016/j.biopha.2019.109316 31387002!ä!31387002 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=31387002&cmd=llinks): Failed to open stream: HTTP request failed! 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Magnesium lithospermate B attenuates renal injury in 5/6 renal ablation/infarction rats by mitochondrial pathway of apoptosis |pdf=|usr=}}{{31387002}} gab.com Text Magnesium lithospermate B attenuates renal injury in 5/6 renal ablation/infarction rats by mitochondrial pathway of apoptosis JO: Biomed Pharmacother http://www.kidney.de/pget.php?&tw=1&pmid=31387002 #FOAvip Apoptosis is closely interconnected with the severity of renal injury. Magnesium lithospermate B (MLB) extracted from Salviae miltiorrhizae radix showed a wide range of renoprotective effects. However, the underlying mechanisms under beneficial effects have not been elucidated. This study was conducted to investigate whether MLB could mediate renal protection and attenuate apoptosis by mitochondrial pathway. In the present study, the rat model of chronic renal failure (CRF) was established by the 5/6 renal ablation/infarction (A/I) operation. 28 days after the surgery, 30 rats were randomly divided into three groups: sham group, 5/6 (A/I) group and 5/6 (A/I) + MLB group. After 56 days of treatment, we detected the severity of kidney injury, the degree of mitochondrial bax oligomerization and cytochrome c release along with the expression of P53 protein. Our results showed that MLB markedly attenuated kidney injury and apoptosis in 5/6 (A/I) model rats with CRF. MLB effectively inhibited mitochondrial bax accumulation and release of cytochrome c into the cytosol and down-regulated the levels of p53 phosphorylation and acetylation. These data showed that MLB could contribute to renal protection by inhibiting mitochondrial pathway of apoptosis. Twit Text FOAVip Magnesium lithospermate B attenuates renal injury in 5/6 renal ablation/infarction rats by mitochondrial pathway of apoptosis ????Biomed Pharmacother http://www.kidney.de/pget.php?&tw=1&pmid=31387002 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=31387002 #FOAvip English Wikipedia <ref>{{Cite pmid|31387002}}</ref> Magnesium lithospermate B attenuates renal injury in 5/6 renal ablation/infarction rats by mitochondrial pathway of apoptosis #MMPMID31387002 Wang M; Yang L; Yang J; Zhou Y; Wang C Biomed Pharmacother 2019[Oct]; 118 (ä): 109316 PMID31387002show ga Apoptosis is closely interconnected with the severity of renal injury. Magnesium lithospermate B (MLB) extracted from Salviae miltiorrhizae radix showed a wide range of renoprotective effects. However, the underlying mechanisms under beneficial effects have not been elucidated. This study was conducted to investigate whether MLB could mediate renal protection and attenuate apoptosis by mitochondrial pathway. In the present study, the rat model of chronic renal failure (CRF) was established by the 5/6 renal ablation/infarction (A/I) operation. 28 days after the surgery, 30 rats were randomly divided into three groups: sham group, 5/6 (A/I) group and 5/6 (A/I) + MLB group. After 56 days of treatment, we detected the severity of kidney injury, the degree of mitochondrial bax oligomerization and cytochrome c release along with the expression of P53 protein. Our results showed that MLB markedly attenuated kidney injury and apoptosis in 5/6 (A/I) model rats with CRF. MLB effectively inhibited mitochondrial bax accumulation and release of cytochrome c into the cytosol and down-regulated the levels of p53 phosphorylation and acetylation. These data showed that MLB could contribute to renal protection by inhibiting mitochondrial pathway of apoptosis. |Animals[MESH] |Apoptosis/*drug effects[MESH] |Cytochromes c/metabolism[MESH] |Cytosol/metabolism[MESH] |Disease Models, Animal[MESH] |Drugs, Chinese Herbal/*pharmacology[MESH] |Kidney/drug effects/*pathology[MESH] |Male[MESH] |Mitochondria/drug effects/*pathology[MESH] |Protein Multimerization[MESH] |Rats, Sprague-Dawley[MESH] |Renal Insufficiency, Chronic/pathology[MESH] |Tumor Suppressor Protein p53/metabolism[MESH]Magnesium lithospermate B attenuates renal injury in 5/6 renal ablati(epmc).pdf DeepDyve Pubget Overpricing