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10.1038/s41573-019-0036-1 http://scihub22266oqcxt.onion/10.1038/s41573-019-0036-1 31477883!7097195!31477883     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\31477883.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Rev+Drug+Discov 2019 ; 18 (12): 923-948 Nephropedia Template TP {{tp|p=31477883|t=2019. Lysosomes as a therapeutic target |pdf=|usr=}}{{31477883}} gab.com Text Lysosomes as a therapeutic target JO: Nat Rev Drug Discov http://www.kidney.de/pget.php?&tw=1&pmid=31477883 #FOAvip Lysosomes are membrane-bound organelles with roles in processes involved in degrading and recycling cellular waste, cellular signalling and energy metabolism. Defects in genes encoding lysosomal proteins cause lysosomal storage disorders, in which enzyme replacement therapy has proved successful. Growing evidence also implicates roles for lysosomal dysfunction in more common diseases including inflammatory and autoimmune disorders, neurodegenerative diseases, cancer and metabolic disorders. With a focus on lysosomal dysfunction in autoimmune disorders and neurodegenerative diseases - including lupus, rheumatoid arthritis, multiple sclerosis, Alzheimer disease and Parkinson disease - this Review critically analyses progress and opportunities for therapeutically targeting lysosomal proteins and processes, particularly with small molecules and peptide drugs. Twit Text FOAVip Lysosomes as a therapeutic target ????Nat Rev Drug Discov http://www.kidney.de/pget.php?&tw=1&pmid=31477883 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=31477883 #FOAvip English Wikipedia <ref>{{Cite pmid|31477883}}</ref> Lysosomes as a therapeutic target #MMPMID31477883 Bonam SR; Wang F; Muller S Nat Rev Drug Discov 2019[Dec]; 18 (12): 923-948 PMID31477883show ga Lysosomes are membrane-bound organelles with roles in processes involved in degrading and recycling cellular waste, cellular signalling and energy metabolism. Defects in genes encoding lysosomal proteins cause lysosomal storage disorders, in which enzyme replacement therapy has proved successful. Growing evidence also implicates roles for lysosomal dysfunction in more common diseases including inflammatory and autoimmune disorders, neurodegenerative diseases, cancer and metabolic disorders. With a focus on lysosomal dysfunction in autoimmune disorders and neurodegenerative diseases - including lupus, rheumatoid arthritis, multiple sclerosis, Alzheimer disease and Parkinson disease - this Review critically analyses progress and opportunities for therapeutically targeting lysosomal proteins and processes, particularly with small molecules and peptide drugs. |*Enzyme Replacement Therapy[MESH] |Animals[MESH] |Energy Metabolism[MESH] |Humans[MESH] |Lysosomal Storage Diseases/metabolism/*therapy[MESH] |Lysosomes/*metabolism[MESH] |Neurodegenerative Diseases/metabolism/*therapy[MESH]Lysosomes as a therapeutic target (epmc).pdf DeepDyve Pubget Overpricing