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10.3389/fimmu.2019.02725 http://scihub22266oqcxt.onion/10.3389/fimmu.2019.02725 31849944!6896820!31849944     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=31849944&cmd=llinks): Failed to open stream: HTTP request failed! 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Low-Density Granulocytes Are a Novel Immunopathological Feature in Both Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder |pdf=|usr=}}{{31849944}} gab.com Text Low-Density Granulocytes Are a Novel Immunopathological Feature in Both Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=31849944 #FOAvip Objective: To investigate whether low-density granulocytes (LDGs) are an immunophenotypic feature of patients with multiple sclerosis (MS) or neuromyelitis optica spectrum disorder (NMOSD). Methods: Blood samples were collected from 20 patients with NMOSD and 17 patients with MS, as well as from 15 patients with Systemic Lupus Erythematosus (SLE) and 23 Healthy Donors (HD). We isolated peripheral blood mononuclear cells (PBMCs) with density gradient separation and stained the cells with antibodies against CD14, CD15, CD16, and CD45, and analyzed the cells by flow cytometry or imaging flow cytometry. We defined LDGs as CD14(-)CD15(high) and calculated their share in total PBMC leukocytes (CD45(+)) as well as the share of CD16(hi) LDGs. Clinical data on disease course, medication, and antibody status were obtained. Results: LDGs were significantly more common in MS and NMOSD than in HDs, comparable to SLE samples (median values HD 0.2%, MS 0.9%, NMOSD 2.1%, SLE 4.3%). 0/23 of the HDs, but 17/20 NMOSD and 11/17 MS samples as well as 13/15 SLE samples had at least 0.7 % LDGs. NMOSD patients without continuous immunosuppressive treatment had significantly more LDGs compared to their treated counterparts. LDG nuclear morphology ranged from segmented to rounded, suggesting a heterogeneity within the group. Conclusion: LDGs are a feature of the immunophenotype in some patients with MS and NMOSD. Twit Text FOAVip Low-Density Granulocytes Are a Novel Immunopathological Feature in Both Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=31849944 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=31849944 #FOAvip English Wikipedia <ref>{{Cite pmid|31849944}}</ref> Low-Density Granulocytes Are a Novel Immunopathological Feature in Both Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder #MMPMID31849944 Ostendorf L; Mothes R; van Koppen S; Lindquist RL; Bellmann-Strobl J; Asseyer S; Ruprecht K; Alexander T; Niesner RA; Hauser AE; Paul F; Radbruch H Front Immunol 2019[]; 10 (ä): 2725 PMID31849944show ga Objective: To investigate whether low-density granulocytes (LDGs) are an immunophenotypic feature of patients with multiple sclerosis (MS) or neuromyelitis optica spectrum disorder (NMOSD). Methods: Blood samples were collected from 20 patients with NMOSD and 17 patients with MS, as well as from 15 patients with Systemic Lupus Erythematosus (SLE) and 23 Healthy Donors (HD). We isolated peripheral blood mononuclear cells (PBMCs) with density gradient separation and stained the cells with antibodies against CD14, CD15, CD16, and CD45, and analyzed the cells by flow cytometry or imaging flow cytometry. We defined LDGs as CD14(-)CD15(high) and calculated their share in total PBMC leukocytes (CD45(+)) as well as the share of CD16(hi) LDGs. Clinical data on disease course, medication, and antibody status were obtained. Results: LDGs were significantly more common in MS and NMOSD than in HDs, comparable to SLE samples (median values HD 0.2%, MS 0.9%, NMOSD 2.1%, SLE 4.3%). 0/23 of the HDs, but 17/20 NMOSD and 11/17 MS samples as well as 13/15 SLE samples had at least 0.7 % LDGs. NMOSD patients without continuous immunosuppressive treatment had significantly more LDGs compared to their treated counterparts. LDG nuclear morphology ranged from segmented to rounded, suggesting a heterogeneity within the group. Conclusion: LDGs are a feature of the immunophenotype in some patients with MS and NMOSD. |*Biomarkers[MESH] |Adult[MESH] |Autoimmunity[MESH] |Case-Control Studies[MESH] |Disease Susceptibility[MESH] |Female[MESH] |Granulocytes/*metabolism[MESH] |Humans[MESH] |Immunophenotyping[MESH] |Leukocyte Count[MESH] |Leukocytes, Mononuclear/metabolism[MESH] |Lupus Erythematosus, Systemic[MESH] |Male[MESH] |Middle Aged[MESH] |Multiple Sclerosis/*diagnosis/etiology/*metabolism[MESH]Low-Density Granulocytes Are a Novel Immunopathological Feature in Bot(epmc).pdf DeepDyve Pubget Overpricing