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10.1111/jcmm.15027 http://scihub22266oqcxt.onion/10.1111/jcmm.15027 31997584!7131951!31997584     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=31997584&cmd=llinks): Failed to open stream: HTTP request failed! 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Staphylococcus aureus facilitates its survival in bovine macrophages by blocking autophagic flux |pdf=|usr=}}{{31997584}} gab.com Text Staphylococcus aureus facilitates its survival in bovine macrophages by blocking autophagic flux JO: J Cell Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=31997584 #FOAvip Staphylococcus aureus is a pathogen that is the causative agent of several human and veterinary infections and plays a critical role in the clinical and subclinical mastitis of cattle. Autophagy is a conserved pathogen defence mechanism in eukaryotes. Studies have reported that S aureus can subvert autophagy and survive in cells. Staphylococcus aureus survival in cells is an important cause of chronic persistent mastitis infection. However, it is unclear whether S aureus can escape autophagy in innate immune cells. In this study, initiation of autophagy due to the presence of S aureus was detected in bovine macrophages. We observed autophagic vacuoles increased after S aureus infection of bovine macrophages by transmission electron microscopy (TEM). It was also found that S aureus-infected bovine macrophages increased the expression of LC3 at different times(0, 0.5, 1, 1.5, 2, 2.5, 3 and 4 hours). Data also showed the accumulation of p62 induced by S aureus infection. Application of autophagy regulatory agents showed that the degradation of p62 was blocked in S aureus induced bovine macrophages. In addition, we also found that the accumulation of autophagosomes promotes S aureus to survive in macrophage cells. In conclusion, this study indicates that autophagy occurs in S aureus-infected bovine macrophages but is blocked at a later stage of autophagy. The accumulation of autophagosomes facilitates the survival of S aureus in bovine macrophages. These findings provide new insights into the interaction of S aureus with autophagy in bovine macrophages. Twit Text FOAVip Staphylococcus aureus facilitates its survival in bovine macrophages by blocking autophagic flux ????J Cell Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=31997584 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=31997584 #FOAvip English Wikipedia <ref>{{Cite pmid|31997584}}</ref> Staphylococcus aureus facilitates its survival in bovine macrophages by blocking autophagic flux #MMPMID31997584 Cai J; Li J; Zhou Y; Wang J; Li J; Cui L; Meng X; Zhu G; Wang H J Cell Mol Med 2020[Mar]; 24 (6): 3460-3468 PMID31997584show ga Staphylococcus aureus is a pathogen that is the causative agent of several human and veterinary infections and plays a critical role in the clinical and subclinical mastitis of cattle. Autophagy is a conserved pathogen defence mechanism in eukaryotes. Studies have reported that S aureus can subvert autophagy and survive in cells. Staphylococcus aureus survival in cells is an important cause of chronic persistent mastitis infection. However, it is unclear whether S aureus can escape autophagy in innate immune cells. In this study, initiation of autophagy due to the presence of S aureus was detected in bovine macrophages. We observed autophagic vacuoles increased after S aureus infection of bovine macrophages by transmission electron microscopy (TEM). It was also found that S aureus-infected bovine macrophages increased the expression of LC3 at different times(0, 0.5, 1, 1.5, 2, 2.5, 3 and 4 hours). Data also showed the accumulation of p62 induced by S aureus infection. Application of autophagy regulatory agents showed that the degradation of p62 was blocked in S aureus induced bovine macrophages. In addition, we also found that the accumulation of autophagosomes promotes S aureus to survive in macrophage cells. In conclusion, this study indicates that autophagy occurs in S aureus-infected bovine macrophages but is blocked at a later stage of autophagy. The accumulation of autophagosomes facilitates the survival of S aureus in bovine macrophages. These findings provide new insights into the interaction of S aureus with autophagy in bovine macrophages. |Animals[MESH] |Autophagosomes/*immunology[MESH] |Autophagy/*immunology[MESH] |Cattle[MESH] |Cell Line[MESH] |Female[MESH] |Macrophages/immunology/*microbiology[MESH] |Mastitis, Bovine/immunology/*microbiology/pathology[MESH] |Microtubule-Associated Proteins/metabolism[MESH] |Receptors, Immunologic/immunology[MESH] |Staphylococcal Infections/immunology/pathology/*veterinary[MESH]Staphylococcus aureus facilitates its survival in bovine macrophages b(epmc).pdf DeepDyve Pubget Overpricing