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10.3390/ijms21030840 http://scihub22266oqcxt.onion/10.3390/ijms21030840 32012923!7043221!32012923     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32012923&cmd=llinks): Failed to open stream: HTTP request failed! 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MicroRNAs and Neutrophil Activation Markers Predict Venous Thrombosis in Pancreatic Ductal Adenocarcinoma and Distal Extrahepatic Cholangiocarcinoma |pdf=|usr=}}{{32012923}} gab.com Text MicroRNAs and Neutrophil Activation Markers Predict Venous Thrombosis in Pancreatic Ductal Adenocarcinoma and Distal Extrahepatic Cholangiocarcinoma JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=32012923 #FOAvip Cancer-associated venous thrombosis (VTE) increases mortality and morbidity. However, limited tools are available to identify high risk patients. Upon activation, neutrophils release their content through different mechanisms, thereby prompting thrombosis. We explored plasma microRNAs (miRNAs) and neutrophil activation markers to predict VTE in pancreatic ductal adenocarcinoma (PDAC) and distal extrahepatic cholangiocarcinoma (DECC). Twenty-six PDAC and 6 DECC patients recruited at cancer diagnosis, were examined for deep vein thrombosis and pulmonary embolisms, and were then followed-up with clinical examinations, blood collections, and biCUS. Ten patients developed VTE and were compared with 22 age- and sex-matched controls. miRNA expression levels were measured at diagnosis and right before VTE, and neutrophil activation markers (cell-free DNA, nucleosomes, calprotectin, and myeloperoxidase) were measured in every sample obtained during follow-up. We obtained a profile of 7 miRNAs able to estimate the risk of future VTE at diagnosis (AUC = 0.95; 95% Confidence Interval (CI) (0.987, 1)) with targets involved in the pancreatic cancer and complement and coagulation cascades pathways. Seven miRNAs were up- or down-regulated before VTE compared with diagnosis. We obtained a predictive model of VTE with calprotectin as predictor (AUC = 0.77; 95% CI (0.57, 0.95)). This is the first study that addresses the ability of plasma miRNAs and neutrophil activation markers to predict VTE in PDAC and DECC. Twit Text FOAVip MicroRNAs and Neutrophil Activation Markers Predict Venous Thrombosis in Pancreatic Ductal Adenocarcinoma and Distal Extrahepatic Cholangiocarcinoma ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=32012923 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32012923 #FOAvip English Wikipedia <ref>{{Cite pmid|32012923}}</ref> MicroRNAs and Neutrophil Activation Markers Predict Venous Thrombosis in Pancreatic Ductal Adenocarcinoma and Distal Extrahepatic Cholangiocarcinoma #MMPMID32012923 Oto J; Navarro S; Larsen AC; Solmoirago MJ; Plana E; Hervas D; Fernandez-Pardo A; Espana F; Kristensen SR; Thorlacius-Ussing O; Medina P Int J Mol Sci 2020[Jan]; 21 (3): ä PMID32012923show ga Cancer-associated venous thrombosis (VTE) increases mortality and morbidity. However, limited tools are available to identify high risk patients. Upon activation, neutrophils release their content through different mechanisms, thereby prompting thrombosis. We explored plasma microRNAs (miRNAs) and neutrophil activation markers to predict VTE in pancreatic ductal adenocarcinoma (PDAC) and distal extrahepatic cholangiocarcinoma (DECC). Twenty-six PDAC and 6 DECC patients recruited at cancer diagnosis, were examined for deep vein thrombosis and pulmonary embolisms, and were then followed-up with clinical examinations, blood collections, and biCUS. Ten patients developed VTE and were compared with 22 age- and sex-matched controls. miRNA expression levels were measured at diagnosis and right before VTE, and neutrophil activation markers (cell-free DNA, nucleosomes, calprotectin, and myeloperoxidase) were measured in every sample obtained during follow-up. We obtained a profile of 7 miRNAs able to estimate the risk of future VTE at diagnosis (AUC = 0.95; 95% Confidence Interval (CI) (0.987, 1)) with targets involved in the pancreatic cancer and complement and coagulation cascades pathways. Seven miRNAs were up- or down-regulated before VTE compared with diagnosis. We obtained a predictive model of VTE with calprotectin as predictor (AUC = 0.77; 95% CI (0.57, 0.95)). This is the first study that addresses the ability of plasma miRNAs and neutrophil activation markers to predict VTE in PDAC and DECC. |Aged[MESH] |Aged, 80 and over[MESH] |Bile Duct Neoplasms/*complications/genetics/immunology[MESH] |Carcinoma, Pancreatic Ductal/*complications/genetics/immunology[MESH] |Case-Control Studies[MESH] |Cholangiocarcinoma/*complications/genetics/immunology[MESH] |Female[MESH] |Gene Expression Regulation, Neoplastic[MESH] |Humans[MESH] |Leukocyte L1 Antigen Complex/metabolism[MESH] |Male[MESH] |MicroRNAs/*blood[MESH] |Middle Aged[MESH] |Neutrophil Activation[MESH] |Neutrophils/*metabolism[MESH] |Nucleosomes/metabolism[MESH] |Pancreatic Neoplasms/*complications/genetics/immunology[MESH] |Peroxidase/metabolism[MESH] |Prospective Studies[MESH]MicroRNAs and Neutrophil Activation Markers Predict Venous Thrombosis (epmc).pdf DeepDyve Pubget Overpricing