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10.1038/s41598-020-59355-y http://scihub22266oqcxt.onion/10.1038/s41598-020-59355-y 32047249!7012919!32047249     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32047249&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\32047249.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2020 ; 10 (1): 2333 Nephropedia Template TP {{tp|p=32047249|t=2020. TRPM7 contributes to progressive nephropathy |pdf=|usr=}}{{32047249}} gab.com Text TRPM7 contributes to progressive nephropathy JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=32047249 #FOAvip TRPM7 belongs to the Transient Receptor Potential Melastatin family of ion channels and is a divalent cation-conducting ion channel fused with a functional kinase. TRPM7 plays a key role in a variety of diseases, including neuronal death in ischemia, cancer, cardiac atrial fibrillation, malaria invasion. TRPM7 is aberrantly over-expressed in lung, liver and heart fibrosis. It is also overexpressed after renal ischemia-reperfusion, an event that induces kidney injury and fibrosis. However, the role of TRPM7 in kidney fibrosis is unclear. Using the unilateral ureteral obstruction (UUO) mouse model, we examined whether TRPM7 contributes to progressive renal damage and fibrosis. We find that TRPM7 expression increases in UUO kidneys. Systemic application of NS8593, a known TRPM7 inhibitor, prevents kidney atrophy in UUO kidneys, retains tubular formation, and reduces TRPM7 expression to normal levels. Cell proliferation of both tubular epithelial cells and interstitial cells is reduced by NS8593 treatment in UUO kidneys, as are TGF-beta1/Smad signaling events. We conclude that TRPM7 is upregulated during inflammatory renal damage and propose that pharmacological intervention targeting TRPM7 may prove protective in progressive kidney fibrosis. Twit Text FOAVip TRPM7 contributes to progressive nephropathy ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=32047249 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32047249 #FOAvip English Wikipedia <ref>{{Cite pmid|32047249}}</ref> TRPM7 contributes to progressive nephropathy #MMPMID32047249 Suzuki S; Penner R; Fleig A Sci Rep 2020[Feb]; 10 (1): 2333 PMID32047249show ga TRPM7 belongs to the Transient Receptor Potential Melastatin family of ion channels and is a divalent cation-conducting ion channel fused with a functional kinase. TRPM7 plays a key role in a variety of diseases, including neuronal death in ischemia, cancer, cardiac atrial fibrillation, malaria invasion. TRPM7 is aberrantly over-expressed in lung, liver and heart fibrosis. It is also overexpressed after renal ischemia-reperfusion, an event that induces kidney injury and fibrosis. However, the role of TRPM7 in kidney fibrosis is unclear. Using the unilateral ureteral obstruction (UUO) mouse model, we examined whether TRPM7 contributes to progressive renal damage and fibrosis. We find that TRPM7 expression increases in UUO kidneys. Systemic application of NS8593, a known TRPM7 inhibitor, prevents kidney atrophy in UUO kidneys, retains tubular formation, and reduces TRPM7 expression to normal levels. Cell proliferation of both tubular epithelial cells and interstitial cells is reduced by NS8593 treatment in UUO kidneys, as are TGF-beta1/Smad signaling events. We conclude that TRPM7 is upregulated during inflammatory renal damage and propose that pharmacological intervention targeting TRPM7 may prove protective in progressive kidney fibrosis. |1-Naphthylamine/*analogs & derivatives/pharmacology[MESH] |Animals[MESH] |Disease Models, Animal[MESH] |Fibrosis/etiology/metabolism/*pathology[MESH] |Kidney Diseases/etiology/metabolism/*pathology[MESH] |Male[MESH] |Mice[MESH] |Mice, Inbred C57BL[MESH] |Signal Transduction[MESH] |TRPM Cation Channels/antagonists & inhibitors/genetics/*metabolism[MESH] |Transforming Growth Factor beta1/genetics/*metabolism[MESH]TRPM7 contributes to progressive nephropathy (epmc).pdf DeepDyve Pubget Overpricing