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10.1016/j.cmi.2020.02.018 http://scihub22266oqcxt.onion/10.1016/j.cmi.2020.02.018 32120038!ä!32120038 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32120038&cmd=llinks): Failed to open stream: HTTP request failed! 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Elevation of serum ferritin levels for predicting a poor outcome in hospitalized patients with influenza infection |pdf=|usr=}}{{32120038}} gab.com Text Elevation of serum ferritin levels for predicting a poor outcome in hospitalized patients with influenza infection JO: Clin Microbiol Infect http://www.kidney.de/pget.php?&tw=1&pmid=32120038 #FOAvip OBJECTIVES: There is increasing evidence that ferritin is a key marker of macrophage activation, but its potential role in influenza infection remains unexplored. Our aim was to assess whether hyperferritinaemia (ferritin >/=500 ng/mL) could be a marker of poor prognosis in hospitalized patients with confirmed influenza A infection. METHODS: We prospectively recruited all hospitalized adult patients who tested positive for the influenza A rRT-PCR assay performed on respiratory samples in two consecutive influenza periods (2016-17 and 2017-18). Poor outcome was defined as the presence of at least one of the following: respiratory failure, admission to the intensive care unit, or in-hospital mortality. RESULTS: Among 494 patients, 68 (14%) developed poor outcomes; 112 patients (23%) had hyperferritinaemia (39/68, 57% in the poor-outcome group versus 73/426, 17% in the remaining patients, p < 0.0001). Median serum ferritin levels were significantly higher in the subgroup of patients with poor outcomes (609 ng/mL, range 231-967 versus 217 ng/mL, range 140-394, p < 0.0001). In multivariate analysis, hyperferritinaemia was associated with a five-fold increase in the odds ratio of developing poor outcome. After adjusting for classic influenza risk factors, ferritin remained as a significant predictive factor in all exploratory models. Ferritin levels had a good discriminative capacity with an area under the ROC curve of 0.72 (95% confidence interval (CI) 0.65-0.8, p < 0.001) and an overall diagnostic accuracy for predicting poor outcome of 79.3% (95%CI 75.4-82.7%). CONCLUSIONS: Serum ferritin may discriminate a subgroup of patients with influenza infection who have a higher risk of developing a poor outcome. Twit Text FOAVip Elevation of serum ferritin levels for predicting a poor outcome in hospitalized patients with influenza infection ????Clin Microbiol Infect http://www.kidney.de/pget.php?&tw=1&pmid=32120038 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32120038 #FOAvip English Wikipedia <ref>{{Cite pmid|32120038}}</ref> Elevation of serum ferritin levels for predicting a poor outcome in hospitalized patients with influenza infection #MMPMID32120038 Lalueza A; Ayuso B; Arrieta E; Trujillo H; Folgueira D; Cueto C; Serrano A; Laureiro J; Arevalo-Canas C; Castillo C; Diaz-Pedroche C; Lumbreras C Clin Microbiol Infect 2020[Nov]; 26 (11): 1557.e9-1557.e15 PMID32120038show ga OBJECTIVES: There is increasing evidence that ferritin is a key marker of macrophage activation, but its potential role in influenza infection remains unexplored. Our aim was to assess whether hyperferritinaemia (ferritin >/=500 ng/mL) could be a marker of poor prognosis in hospitalized patients with confirmed influenza A infection. METHODS: We prospectively recruited all hospitalized adult patients who tested positive for the influenza A rRT-PCR assay performed on respiratory samples in two consecutive influenza periods (2016-17 and 2017-18). Poor outcome was defined as the presence of at least one of the following: respiratory failure, admission to the intensive care unit, or in-hospital mortality. RESULTS: Among 494 patients, 68 (14%) developed poor outcomes; 112 patients (23%) had hyperferritinaemia (39/68, 57% in the poor-outcome group versus 73/426, 17% in the remaining patients, p < 0.0001). Median serum ferritin levels were significantly higher in the subgroup of patients with poor outcomes (609 ng/mL, range 231-967 versus 217 ng/mL, range 140-394, p < 0.0001). In multivariate analysis, hyperferritinaemia was associated with a five-fold increase in the odds ratio of developing poor outcome. After adjusting for classic influenza risk factors, ferritin remained as a significant predictive factor in all exploratory models. Ferritin levels had a good discriminative capacity with an area under the ROC curve of 0.72 (95% confidence interval (CI) 0.65-0.8, p < 0.001) and an overall diagnostic accuracy for predicting poor outcome of 79.3% (95%CI 75.4-82.7%). CONCLUSIONS: Serum ferritin may discriminate a subgroup of patients with influenza infection who have a higher risk of developing a poor outcome. |*Up-Regulation[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |Critical Care/statistics & numerical data[MESH] |Female[MESH] |Ferritins/*blood[MESH] |Hospital Mortality[MESH] |Hospitalization[MESH] |Humans[MESH] |Influenza A virus/*genetics[MESH] |Influenza, Human/blood/complications/*diagnosis/mortality[MESH] |Male[MESH] |Middle Aged[MESH] |Prognosis[MESH] |Prospective Studies[MESH]Elevation of serum ferritin levels for predicting a poor outcome in ho(epmc).pdf DeepDyve Pubget Overpricing