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10.1371/journal.ppat.1008429 http://scihub22266oqcxt.onion/10.1371/journal.ppat.1008429 32208449!7122826!32208449     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32208449&cmd=llinks): Failed to open stream: HTTP request failed! 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BRD4 inhibition exerts anti-viral activity through DNA damage-dependent innate immune responses |pdf=|usr=}}{{32208449}} gab.com Text BRD4 inhibition exerts anti-viral activity through DNA damage-dependent innate immune responses JO: PLoS Pathog http://www.kidney.de/pget.php?&tw=1&pmid=32208449 #FOAvip Chromatin dynamics regulated by epigenetic modification is crucial in genome stability and gene expression. Various epigenetic mechanisms have been identified in the pathogenesis of human diseases. Here, we examined the effects of ten epigenetic agents on pseudorabies virus (PRV) infection by using GFP-reporter assays. Inhibitors of bromodomain protein 4 (BRD4), which receives much more attention in cancer than viral infection, was found to exhibit substantial anti-viral activity against PRV as well as a range of DNA and RNA viruses. We further demonstrated that BRD4 inhibition boosted a robust innate immune response. BRD4 inhibition also de-compacted chromatin structure and induced the DNA damage response, thereby triggering the activation of cGAS-mediated innate immunity and increasing host resistance to viral infection both in vitro and in vivo. Mechanistically, the inhibitory effect of BRD4 inhibition on viral infection was mainly attributed to the attenuation of viral attachment. Our findings reveal a unique mechanism through which BRD4 inhibition restrains viral infection and points to its potent therapeutic value for viral infectious diseases. Twit Text FOAVip BRD4 inhibition exerts anti-viral activity through DNA damage-dependent innate immune responses ????PLoS Pathog http://www.kidney.de/pget.php?&tw=1&pmid=32208449 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32208449 #FOAvip English Wikipedia <ref>{{Cite pmid|32208449}}</ref> BRD4 inhibition exerts anti-viral activity through DNA damage-dependent innate immune responses #MMPMID32208449 Wang J; Li GL; Ming SL; Wang CF; Shi LJ; Su BQ; Wu HT; Zeng L; Han YQ; Liu ZH; Jiang DW; Du YK; Li XD; Zhang GP; Yang GY; Chu BB PLoS Pathog 2020[Mar]; 16 (3): e1008429 PMID32208449show ga Chromatin dynamics regulated by epigenetic modification is crucial in genome stability and gene expression. Various epigenetic mechanisms have been identified in the pathogenesis of human diseases. Here, we examined the effects of ten epigenetic agents on pseudorabies virus (PRV) infection by using GFP-reporter assays. Inhibitors of bromodomain protein 4 (BRD4), which receives much more attention in cancer than viral infection, was found to exhibit substantial anti-viral activity against PRV as well as a range of DNA and RNA viruses. We further demonstrated that BRD4 inhibition boosted a robust innate immune response. BRD4 inhibition also de-compacted chromatin structure and induced the DNA damage response, thereby triggering the activation of cGAS-mediated innate immunity and increasing host resistance to viral infection both in vitro and in vivo. Mechanistically, the inhibitory effect of BRD4 inhibition on viral infection was mainly attributed to the attenuation of viral attachment. Our findings reveal a unique mechanism through which BRD4 inhibition restrains viral infection and points to its potent therapeutic value for viral infectious diseases. |*Immunity, Innate[MESH] |A549 Cells[MESH] |Animals[MESH] |Cell Cycle Proteins/*immunology[MESH] |Chlorocebus aethiops[MESH] |DNA Damage/*immunology[MESH] |DNA Virus Infections/immunology[MESH] |DNA Viruses/*immunology[MESH] |Dogs[MESH] |Female[MESH] |HEK293 Cells[MESH] |HeLa Cells[MESH] |Humans[MESH] |Madin Darby Canine Kidney Cells[MESH] |Mice[MESH] |Mice, Inbred BALB C[MESH] |NIH 3T3 Cells[MESH] |Nuclear Proteins/*immunology[MESH] |RAW 264.7 Cells[MESH] |RNA Virus Infections/immunology[MESH] |RNA Viruses/*immunology[MESH] |Swine[MESH] |Transcription Factors/*immunology[MESH]BRD4 inhibition exerts anti-viral activity through DNA damage-dependen(epmc).pdf DeepDyve Pubget Overpricing