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10.1038/s41467-020-15562-9 http://scihub22266oqcxt.onion/10.1038/s41467-020-15562-9 32221306!7100515!32221306     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\32221306.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2020 ; 11 (1): 1620 Nephropedia Template TP {{tp|p=32221306|t=2020. Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV |pdf=|usr=}}{{32221306}} gab.com Text Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=32221306 #FOAvip Since 2002, beta coronaviruses (CoV) have caused three zoonotic outbreaks, SARS-CoV in 2002-2003, MERS-CoV in 2012, and the newly emerged SARS-CoV-2 in late 2019. However, little is currently known about the biology of SARS-CoV-2. Here, using SARS-CoV-2 S protein pseudovirus system, we confirm that human angiotensin converting enzyme 2 (hACE2) is the receptor for SARS-CoV-2, find that SARS-CoV-2 enters 293/hACE2 cells mainly through endocytosis, that PIKfyve, TPC2, and cathepsin L are critical for entry, and that SARS-CoV-2 S protein is less stable than SARS-CoV S. Polyclonal anti-SARS S1 antibodies T62 inhibit entry of SARS-CoV S but not SARS-CoV-2 S pseudovirions. Further studies using recovered SARS and COVID-19 patients' sera show limited cross-neutralization, suggesting that recovery from one infection might not protect against the other. Our results present potential targets for development of drugs and vaccines for SARS-CoV-2. Twit Text FOAVip Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=32221306 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32221306 #FOAvip English Wikipedia <ref>{{Cite pmid|32221306}}</ref> Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV #MMPMID32221306 Ou X; Liu Y; Lei X; Li P; Mi D; Ren L; Guo L; Guo R; Chen T; Hu J; Xiang Z; Mu Z; Chen X; Chen J; Hu K; Jin Q; Wang J; Qian Z Nat Commun 2020[Mar]; 11 (1): 1620 PMID32221306show ga Since 2002, beta coronaviruses (CoV) have caused three zoonotic outbreaks, SARS-CoV in 2002-2003, MERS-CoV in 2012, and the newly emerged SARS-CoV-2 in late 2019. However, little is currently known about the biology of SARS-CoV-2. Here, using SARS-CoV-2 S protein pseudovirus system, we confirm that human angiotensin converting enzyme 2 (hACE2) is the receptor for SARS-CoV-2, find that SARS-CoV-2 enters 293/hACE2 cells mainly through endocytosis, that PIKfyve, TPC2, and cathepsin L are critical for entry, and that SARS-CoV-2 S protein is less stable than SARS-CoV S. Polyclonal anti-SARS S1 antibodies T62 inhibit entry of SARS-CoV S but not SARS-CoV-2 S pseudovirions. Further studies using recovered SARS and COVID-19 patients' sera show limited cross-neutralization, suggesting that recovery from one infection might not protect against the other. Our results present potential targets for development of drugs and vaccines for SARS-CoV-2. |*Virus Internalization[MESH] |Angiotensin-Converting Enzyme 2[MESH] |Antibodies, Viral/*immunology[MESH] |Betacoronavirus/chemistry/immunology/*physiology[MESH] |Broadly Neutralizing Antibodies/*immunology[MESH] |COVID-19[MESH] |Calcium Channels/metabolism[MESH] |Cathepsin L/metabolism[MESH] |Cathepsins/antagonists & inhibitors/metabolism[MESH] |Cell Fusion[MESH] |Coronavirus Infections/immunology[MESH] |Cross Reactions[MESH] |Endocytosis[MESH] |Giant Cells/physiology[MESH] |HEK293 Cells[MESH] |Humans[MESH] |Neutralization Tests[MESH] |Pandemics[MESH] |Peptidyl-Dipeptidase A/metabolism[MESH] |Phosphatidylinositol 3-Kinases/metabolism[MESH] |Pneumonia, Viral/immunology[MESH] |Protein Domains[MESH] |Protein Multimerization[MESH] |Receptors, Virus/metabolism[MESH] |SARS-CoV-2[MESH] |Severe Acute Respiratory Syndrome/immunology[MESH] |Severe acute respiratory syndrome-related coronavirus/immunology[MESH] |Spike Glycoprotein, Coronavirus/chemistry/*immunology/*metabolism[MESH]Characterization of spike glycoprotein of SARS-CoV-2 on virus entry an(epmc).pdf DeepDyve Pubget Overpricing