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10.1016/j.ijid.2020.03.065

http://scihub22266oqcxt.onion/10.1016/j.ijid.2020.03.065
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suck abstract from ncbi


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pmid32251798      Int+J+Infect+Dis 2020 ; 94 (ä): 49-52
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  • Diagnostic value and dynamic variance of serum antibody in coronavirus disease 2019 #MMPMID32251798
  • Jin Y; Wang M; Zuo Z; Fan C; Ye F; Cai Z; Wang Y; Cui H; Pan K; Xu A
  • Int J Infect Dis 2020[May]; 94 (ä): 49-52 PMID32251798show ga
  • OBJECTIVE: To investigate the diagnostic value of serological testing and dynamic variance of serum antibody in coronavirus disease 2019 (COVID-19). METHODS: This study retrospectively included 43 patients with a laboratory-confirmed infection and 33 patients with a suspected infection, in whom the disease was eventually excluded. The IgM/IgG titer of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was measured by chemiluminescence immunoassay analysis. RESULTS: Compared to molecular detection, the sensitivities of serum IgM and IgG antibodies to diagnose COVID-19 were 48.1% and 88.9%, and the specificities were 100% and 90.9%, respectively.In the COVID-19 group, the IgM-positive rate increased slightly at first and then decreased over time; in contrast, the IgG-positive rate increased to 100% and was higher than IgM at all times. The IgM-positive rate and titer were not significantly different before and after conversion to virus-negative. The IgG-positive rate was up to 90% and not significantly different before and after conversion to virus-negative. However, the median IgG titer after conversion to virus-negative was double that before, and the difference was significant. CONCLUSIONS: Viral serological testing is an effective means of diagnosis for SARS-CoV-2 infection. The positive rate and titer variance of IgG are higher than those of IgM in COVID-19.
  • |Betacoronavirus/*immunology[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/*diagnosis[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Immunoglobulin G/*blood[MESH]
  • |Immunoglobulin M/*blood[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*diagnosis[MESH]
  • |Retrospective Studies[MESH]
  • |SARS-CoV-2[MESH]


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