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10.1111/tid.13286 http://scihub22266oqcxt.onion/10.1111/tid.13286 32279418!7262190!32279418     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32279418&cmd=llinks): Failed to open stream: HTTP request failed! 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Threatening drug-drug interaction in a kidney transplant patient with coronavirus disease 2019 (COVID-19) |pdf=|usr=}}{{32279418}} gab.com Text Threatening drug-drug interaction in a kidney transplant patient with coronavirus disease 2019 (COVID-19) JO: Transpl Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=32279418 #FOAvip During the novel coronavirus pandemic, organ transplant recipients represent a frail susceptible category due to long-term immunosuppressive therapy. For this reason, clinical manifestations may differ from general population and different treatment approaches may be needed. We present the case of a 36-year-old kidney-transplanted woman affected by Senior-Loken syndrome diagnosed with COVID-19 pneumonia after a contact with her positive mother. Initial symptoms were fatigue, dry cough, and coryza; she never had fever nor oxygen supplementation. Hydroxychloroquine and lopinavir/ritonavir were started, and the antiviral drug was replaced with darunavir/cobicistat after 2 days for diarrhea. Immunosuppressant levels were closely monitored, and we observed very high tacrolimus trough levels despite initial dose reduction. The patient was left with steroid therapy alone. The peculiarity of clinical presentation and the management difficulties represent the flagship of our case report. We stress the need for guidelines in transplant recipients with COVID-19 infection with particular regard to the management of therapy. Twit Text FOAVip Threatening drug-drug interaction in a kidney transplant patient with coronavirus disease 2019 (COVID-19) ????Transpl Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=32279418 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32279418 #FOAvip English Wikipedia <ref>{{Cite pmid|32279418}}</ref> Threatening drug-drug interaction in a kidney transplant patient with coronavirus disease 2019 (COVID-19) #MMPMID32279418 Bartiromo M; Borchi B; Botta A; Bagala A; Lugli G; Tilli M; Cavallo A; Xhaferi B; Cutruzzula R; Vaglio A; Bresci S; Larti A; Bartoloni A; Cirami C Transpl Infect Dis 2020[Aug]; 22 (4): e13286 PMID32279418show ga During the novel coronavirus pandemic, organ transplant recipients represent a frail susceptible category due to long-term immunosuppressive therapy. For this reason, clinical manifestations may differ from general population and different treatment approaches may be needed. We present the case of a 36-year-old kidney-transplanted woman affected by Senior-Loken syndrome diagnosed with COVID-19 pneumonia after a contact with her positive mother. Initial symptoms were fatigue, dry cough, and coryza; she never had fever nor oxygen supplementation. Hydroxychloroquine and lopinavir/ritonavir were started, and the antiviral drug was replaced with darunavir/cobicistat after 2 days for diarrhea. Immunosuppressant levels were closely monitored, and we observed very high tacrolimus trough levels despite initial dose reduction. The patient was left with steroid therapy alone. The peculiarity of clinical presentation and the management difficulties represent the flagship of our case report. We stress the need for guidelines in transplant recipients with COVID-19 infection with particular regard to the management of therapy. |*Kidney Transplantation[MESH] |Adult[MESH] |Antiviral Agents/*adverse effects/therapeutic use[MESH] |Betacoronavirus[MESH] |C-Reactive Protein/immunology[MESH] |COVID-19[MESH] |COVID-19 Drug Treatment[MESH] |Ciliopathies/complications[MESH] |Cobicistat/therapeutic use[MESH] |Common Cold/etiology/physiopathology[MESH] |Coronavirus Infections/complications/*drug therapy/immunology/physiopathology[MESH] |Cough/etiology/physiopathology[MESH] |Cytochrome P-450 CYP3A Inhibitors/*adverse effects[MESH] |Darunavir/therapeutic use[MESH] |Deprescriptions[MESH] |Drug Combinations[MESH] |Drug Interactions[MESH] |Enzyme Inhibitors/therapeutic use[MESH] |Fatigue/etiology/physiopathology[MESH] |Female[MESH] |Glucocorticoids/therapeutic use[MESH] |Graft Rejection/*prevention & control[MESH] |Humans[MESH] |Hydroxychloroquine/therapeutic use[MESH] |Immunocompromised Host/immunology[MESH] |Immunosuppressive Agents/*adverse effects[MESH] |Interleukin-10/immunology[MESH] |Interleukin-1beta/immunology[MESH] |Interleukin-6/immunology[MESH] |Interleukin-8/immunology[MESH] |Kidney Diseases, Cystic/complications[MESH] |Kidney Failure, Chronic/etiology/surgery[MESH] |Leber Congenital Amaurosis/complications[MESH] |Lopinavir/*adverse effects[MESH] |Methylprednisolone/therapeutic use[MESH] |Optic Atrophies, Hereditary/complications[MESH] |Pandemics[MESH] |Pneumonia, Viral/complications/*drug therapy/immunology/physiopathology[MESH] |Ritonavir/*adverse effects[MESH] |SARS-CoV-2[MESH] |Severity of Illness Index[MESH]Threatening drug-drug interaction in a kidney transplant patient with (epmc).pdf DeepDyve Pubget Overpricing