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Is the ACE2 Overexpression a Risk Factor for COVID-19 Infection? #MMPMID32279908
Gracia-Ramos AE
Arch Med Res 2020[May]; 51 (4): 345-346 PMID32279908show ga
In the recent coronavirus disease (COVID-19) outbreak, a higher proportion of patients with severe disease were found in older persons with comorbidities. This observation has been related to the use of drugs that can increase the cellular expression of angiotensin-converting enzyme 2 (ACE2) that has been recognized as target to which the virus bind to cells. Although this hypothesis is possible, it may also have other explanations which are discussed.