
| 10.1016/j.virusres.2020.197976
http://scihub22266oqcxt.onion/10.1016/j.virusres.2020.197976
 32294518!7152894!32294518
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Virus+Res 2020 ; 283 (�): 197976 Nephropedia Template TP
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A comprehensive analysis of genome composition and codon usage patterns of emerging coronaviruses #MMPMID32294518Tort FL; Castells M; Cristina JVirus Res 2020[Jul]; 283 (�): 197976 PMID32294518show ga
An outbreak of atypical pneumonia caused by a novel Betacoronavirus (betaCoV), named SARS-CoV-2 has been declared a public health emergency of international concern by the World Health Organization. In order to gain insight into the emergence, evolution and adaptation of SARS-CoV-2 viruses, a comprehensive analysis of genome composition and codon usage of betaCoV circulating in China was performed. A biased nucleotide composition was found for SARS-CoV-2 genome. This bias in genomic composition is reflected in its codon and amino acid usage patterns. The overall codon usage in SARS-CoV-2 is similar among themselves and slightly biased. Most of the highly frequent codons are A- and U-ending, which strongly suggests that mutational bias is the main force shaping codon usage in this virus. Significant differences in relative synonymous codon usage frequencies among SARS-CoV-2 and human cells were found. These differences are due to codon usage preferences.|*Genomics[MESH]|Amino Acids/genetics[MESH]|Animals[MESH]|Betacoronavirus/*classification/*genetics/isolation & purification[MESH]|China/epidemiology[MESH]|Chiroptera/virology[MESH]|Codon Usage/*genetics[MESH]|Communicable Diseases, Emerging/*virology[MESH]|Coronavirus Infections/epidemiology/veterinary/virology[MESH]|Evolution, Molecular[MESH]|Ferrets/virology[MESH]|Gene Expression Regulation, Viral/*genetics[MESH]|Genome, Viral/*genetics[MESH]|Humans[MESH]|Mutagenesis/genetics[MESH]|Open Reading Frames/genetics[MESH]|SARS-CoV-2[MESH]
  
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