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10.1126/science.abb7314 http://scihub22266oqcxt.onion/10.1126/science.abb7314 32303590!7164679!32303590     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32303590&cmd=llinks): Failed to open stream: HTTP request failed! 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Comparative pathogenesis of COVID-19, MERS, and SARS in a nonhuman primate model |pdf=|usr=}}{{32303590}} gab.com Text Comparative pathogenesis of COVID-19, MERS, and SARS in a nonhuman primate model JO: Science http://www.kidney.de/pget.php?&tw=1&pmid=32303590 #FOAvip The current pandemic coronavirus, severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2), was recently identified in patients with an acute respiratory syndrome, coronavirus disease 2019 (COVID-19). To compare its pathogenesis with that of previously emerging coronaviruses, we inoculated cynomolgus macaques with SARS-CoV-2 or Middle East respiratory syndrome (MERS)-CoV and compared the pathology and virology with historical reports of SARS-CoV infections. In SARS-CoV-2-infected macaques, virus was excreted from nose and throat in the absence of clinical signs and detected in type I and II pneumocytes in foci of diffuse alveolar damage and in ciliated epithelial cells of nasal, bronchial, and bronchiolar mucosae. In SARS-CoV infection, lung lesions were typically more severe, whereas they were milder in MERS-CoV infection, where virus was detected mainly in type II pneumocytes. These data show that SARS-CoV-2 causes COVID-19-like disease in macaques and provides a new model to test preventive and therapeutic strategies. Twit Text FOAVip Comparative pathogenesis of COVID-19, MERS, and SARS in a nonhuman primate model ????Science http://www.kidney.de/pget.php?&tw=1&pmid=32303590 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32303590 #FOAvip English Wikipedia <ref>{{Cite pmid|32303590}}</ref> Comparative pathogenesis of COVID-19, MERS, and SARS in a nonhuman primate model #MMPMID32303590 Rockx B; Kuiken T; Herfst S; Bestebroer T; Lamers MM; Oude Munnink BB; de Meulder D; van Amerongen G; van den Brand J; Okba NMA; Schipper D; van Run P; Leijten L; Sikkema R; Verschoor E; Verstrepen B; Bogers W; Langermans J; Drosten C; Fentener van Vlissingen M; Fouchier R; de Swart R; Koopmans M; Haagmans BL Science 2020[May]; 368 (6494): 1012-1015 PMID32303590show ga The current pandemic coronavirus, severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2), was recently identified in patients with an acute respiratory syndrome, coronavirus disease 2019 (COVID-19). To compare its pathogenesis with that of previously emerging coronaviruses, we inoculated cynomolgus macaques with SARS-CoV-2 or Middle East respiratory syndrome (MERS)-CoV and compared the pathology and virology with historical reports of SARS-CoV infections. In SARS-CoV-2-infected macaques, virus was excreted from nose and throat in the absence of clinical signs and detected in type I and II pneumocytes in foci of diffuse alveolar damage and in ciliated epithelial cells of nasal, bronchial, and bronchiolar mucosae. In SARS-CoV infection, lung lesions were typically more severe, whereas they were milder in MERS-CoV infection, where virus was detected mainly in type II pneumocytes. These data show that SARS-CoV-2 causes COVID-19-like disease in macaques and provides a new model to test preventive and therapeutic strategies. |*Disease Models, Animal[MESH] |*Macaca fascicularis[MESH] |Aging[MESH] |Animals[MESH] |Betacoronavirus/isolation & purification/*pathogenicity/physiology[MESH] |COVID-19[MESH] |Coronavirus Infections/*pathology/*virology[MESH] |Female[MESH] |Lung/*pathology/virology[MESH] |Middle East Respiratory Syndrome Coronavirus/isolation & purification/physiology[MESH] |Pandemics[MESH] |Pneumonia, Viral/*pathology/*virology[MESH] |Pulmonary Alveoli/pathology/virology[MESH] |Respiratory System/pathology/virology[MESH] |SARS-CoV-2[MESH] |Severe Acute Respiratory Syndrome/pathology/virology[MESH] |Severe acute respiratory syndrome-related coronavirus/isolation & purification/physiology[MESH] |Virus Replication[MESH]Comparative pathogenesis of COVID-19, MERS, and SARS in a nonhuman pri(epmc).pdf DeepDyve Pubget Overpricing