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Case Report: Hepatotoxicity Associated with the Use of Hydroxychloroquine in a Patient with COVID-19 #MMPMID32314698
Falcao MB; Pamplona de Goes Cavalcanti L; Filgueiras Filho NM; Antunes de Brito CA
Am J Trop Med Hyg 2020[Jun]; 102 (6): 1214-1216 PMID32314698show ga
Hydroxychloroquine (HCQ) has been used for the treatment of novel coronavirus disease (COVID-19) cases. However, evidence of efficacy remains limited, and adverse events can be associated with its use. Here, we report a case of a patient with severe COVID-19 who, after being administered HCQ, exhibited a 10-fold increase in serum levels of transaminases, followed by a rapid decrease after HCQ was withdrawn. Considering the significantly increased use of HCQ during the COVID-19 pandemic, this case alerts us to the potential for HCQ to be associated with hepatotoxicity and the need to monitor liver function during HCQ therapy.