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10.1038/s41467-020-16048-4 http://scihub22266oqcxt.onion/10.1038/s41467-020-16048-4 32332765!7265355!32332765     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32332765&cmd=llinks): Failed to open stream: HTTP request failed! 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Neutralization of SARS-CoV-2 spike pseudotyped virus by recombinant ACE2-Ig |pdf=|usr=}}{{32332765}} gab.com Text Neutralization of SARS-CoV-2 spike pseudotyped virus by recombinant ACE2-Ig JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=32332765 #FOAvip Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan, China, at the end of 2019, and there are currently no specific antiviral treatments or vaccines available. SARS-CoV-2 has been shown to use the same cell entry receptor as SARS-CoV, angiotensin-converting enzyme 2 (ACE2). In this report, we generate a recombinant protein by connecting the extracellular domain of human ACE2 to the Fc region of the human immunoglobulin IgG1. A fusion protein containing an ACE2 mutant with low catalytic activity is also used in this study. The fusion proteins are then characterized. Both fusion proteins have a high binding affinity for the receptor-binding domains of SARS-CoV and SARS-CoV-2 and exhibit desirable pharmacological properties in mice. Moreover, the fusion proteins neutralize virus pseudotyped with SARS-CoV or SARS-CoV-2 spike proteins in vitro. As these fusion proteins exhibit cross-reactivity against coronaviruses, they have potential applications in the diagnosis, prophylaxis, and treatment of SARS-CoV-2. Twit Text FOAVip Neutralization of SARS-CoV-2 spike pseudotyped virus by recombinant ACE2-Ig ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=32332765 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32332765 #FOAvip English Wikipedia <ref>{{Cite pmid|32332765}}</ref> Neutralization of SARS-CoV-2 spike pseudotyped virus by recombinant ACE2-Ig #MMPMID32332765 Lei C; Qian K; Li T; Zhang S; Fu W; Ding M; Hu S Nat Commun 2020[Apr]; 11 (1): 2070 PMID32332765show ga Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan, China, at the end of 2019, and there are currently no specific antiviral treatments or vaccines available. SARS-CoV-2 has been shown to use the same cell entry receptor as SARS-CoV, angiotensin-converting enzyme 2 (ACE2). In this report, we generate a recombinant protein by connecting the extracellular domain of human ACE2 to the Fc region of the human immunoglobulin IgG1. A fusion protein containing an ACE2 mutant with low catalytic activity is also used in this study. The fusion proteins are then characterized. Both fusion proteins have a high binding affinity for the receptor-binding domains of SARS-CoV and SARS-CoV-2 and exhibit desirable pharmacological properties in mice. Moreover, the fusion proteins neutralize virus pseudotyped with SARS-CoV or SARS-CoV-2 spike proteins in vitro. As these fusion proteins exhibit cross-reactivity against coronaviruses, they have potential applications in the diagnosis, prophylaxis, and treatment of SARS-CoV-2. |*Neutralization Tests[MESH] |Angiotensin-Converting Enzyme 2[MESH] |Animals[MESH] |Betacoronavirus/*drug effects/metabolism[MESH] |Binding, Competitive/drug effects[MESH] |Cross Reactions[MESH] |Drug Design[MESH] |Humans[MESH] |Immunoglobulin Fc Fragments/*chemistry/metabolism/pharmacology[MESH] |Immunoglobulin G/*chemistry/metabolism/pharmacology[MESH] |In Vitro Techniques[MESH] |Inhibitory Concentration 50[MESH] |Membrane Fusion/drug effects[MESH] |Mice[MESH] |Mice, Inbred BALB C[MESH] |Mutation[MESH] |Peptide Fragments/chemistry/genetics/metabolism/pharmacology[MESH] |Peptidyl-Dipeptidase A/*chemistry/genetics/pharmacokinetics/pharmacology[MESH] |Protein Domains/genetics[MESH] |Protein Stability[MESH] |Receptors, Virus/antagonists & inhibitors/chemistry/genetics/metabolism[MESH] |Recombinant Fusion Proteins/*chemistry/genetics/pharmacokinetics/*pharmacology[MESH] |SARS-CoV-2[MESH] |Severe acute respiratory syndrome-related coronavirus/drug effects/metabolism[MESH]Neutralization of SARS-CoV-2 spike pseudotyped virus by recombinant AC(epmc).pdf DeepDyve Pubget Overpricing