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10.1016/j.cca.2020.04.026

http://scihub22266oqcxt.onion/10.1016/j.cca.2020.04.026
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suck abstract from ncbi


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pmid32343948      Clin+Chim+Acta 2020 ; 507 (ä): 164-166
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  • IgA-Ab response to spike glycoprotein of SARS-CoV-2 in patients with COVID-19: A longitudinal study #MMPMID32343948
  • Padoan A; Sciacovelli L; Basso D; Negrini D; Zuin S; Cosma C; Faggian D; Matricardi P; Plebani M
  • Clin Chim Acta 2020[Aug]; 507 (ä): 164-166 PMID32343948show ga
  • Validation studies of serological antibody tests must be properly designed for clinical, epidemiological and Public Health objectives such as confirmation of suspected COVID-19 cases, certification of seroconversion after infection, and epidemiological surveillance. We evaluated the kinetics of IgM, IgA and IgG SARS-CoV-2 antibodies in COVID-19 patients with confirmed (rRT-PCR) infection. We found that the IgA response appears and grows early, peaks at week 3, and it is stronger and more persistent than the IgM response. Further longitudinal investigations of virus-specific antibodies functions and of their protective efficacy over time are needed.
  • |Adult[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Antibodies, Viral/*blood[MESH]
  • |Betacoronavirus/*isolation & purification[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/*blood/*diagnosis[MESH]
  • |Female[MESH]
  • |Glycoproteins/*blood[MESH]
  • |Humans[MESH]
  • |Immunoglobulin A/*blood[MESH]
  • |Longitudinal Studies[MESH]
  • |Luminescent Measurements/methods[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*blood/*diagnosis[MESH]
  • |Real-Time Polymerase Chain Reaction/methods[MESH]
  • |SARS-CoV-2[MESH]


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