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10.1080/22221751.2020.1762515

http://scihub22266oqcxt.onion/10.1080/22221751.2020.1762515
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32357808!7273175!32357808
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suck abstract from ncbi


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pmid32357808      Emerg+Microbes+Infect 2020 ; 9 (1): 940-948
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  • Kinetics of SARS-CoV-2 specific IgM and IgG responses in COVID-19 patients #MMPMID32357808
  • Sun B; Feng Y; Mo X; Zheng P; Wang Q; Li P; Peng P; Liu X; Chen Z; Huang H; Zhang F; Luo W; Niu X; Hu P; Wang L; Peng H; Huang Z; Feng L; Li F; Zhang F; Li F; Zhong N; Chen L
  • Emerg Microbes Infect 2020[Dec]; 9 (1): 940-948 PMID32357808show ga
  • The emerging COVID-19 caused by SARS-CoV-2 infection poses severe challenges to global public health. Serum antibody testing is becoming one of the critical methods for the diagnosis of COVID-19 patients. We investigated IgM and IgG responses against SARS-CoV-2 nucleocapsid (N) and spike (S) protein after symptom onset in the intensive care unit (ICU) and non-ICU patients. 130 blood samples from 38 COVID-19 patients were collected. The levels of IgM and IgG specific to N and S protein were detected by ELISA. A series of blood samples were collected along the disease course from the same patient, including 11 ICU patients and 27 non-ICU patients for longitudinal analysis. N and S specific IgM and IgG (N-IgM, N-IgG, S-IgM, S-IgG) in non-ICU patients increased after symptom onset. N-IgM and S-IgM in some non-ICU patients reached a peak in the second week, while N-IgG and S-IgG continued to increase in the third week. The combined detection of N and S specific IgM and IgG could identify up to 75% of SARS-CoV-2 infected patients in the first week. S-IgG was significantly higher in non-ICU patients than in ICU patients in the third week. In contrast, N-IgG was significantly higher in ICU patients than in non-ICU patients. The increase of S-IgG positively correlated with the decrease of C-reactive protein (CRP) in non-ICU patients. N and S specific IgM and IgG increased gradually after symptom onset and can be used for detection of SARS-CoV-2 infection. Analysis of the dynamics of S-IgG may help to predict prognosis.
  • |Aged[MESH]
  • |Antibodies, Viral/blood/*immunology[MESH]
  • |Betacoronavirus/*immunology[MESH]
  • |C-Reactive Protein/analysis/immunology[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Testing[MESH]
  • |Clinical Laboratory Techniques[MESH]
  • |Coronavirus Infections/blood/diagnosis/*immunology[MESH]
  • |Coronavirus Nucleocapsid Proteins[MESH]
  • |Critical Care/statistics & numerical data[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Immunoglobulin G/blood/*immunology[MESH]
  • |Immunoglobulin M/blood/*immunology[MESH]
  • |Kinetics[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Nucleocapsid Proteins/blood/*immunology[MESH]
  • |Pandemics[MESH]
  • |Phosphoproteins[MESH]
  • |Pneumonia, Viral/blood/diagnosis/*immunology[MESH]
  • |SARS-CoV-2[MESH]


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