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How the COVID-19 Overcomes the Battle? An Approach to Virus Structure #MMPMID32361692Ahmadpour D; Ahmadpoor PIran J Kidney Dis 2020[May]; 14 (3): 167-172 PMID32361692show ga
Coronaviruses primarily cause zoonotic infections, however in the past few decades several interspecies transmissions have occurred, the last one by SARS-CoV-2, causing COVID-19 pandemic, posing serious threat to global health. The SARS-CoV-2 spike (S) protein plays an important role in viral attachment, fusion and entry. However, other structural and non-structural SARS-CoV-2 proteins are potential influencers in virus pathogenicity. Among these proteins; Orf3, Orf8, and Orf10 show the least homology to SARSCoV proteins and therefore should be further studied for their abilities to modulate antiviral and inflammatory responses. Here, we discuss how SARS-COV-2 interacts with our immune system.|*Betacoronavirus/genetics/immunology[MESH]|Animals[MESH]|COVID-19[MESH]|Coronavirus Infections/*immunology/*virology[MESH]|Gene Order[MESH]|Genome, Viral/*genetics[MESH]|Humans[MESH]|Immune System/*virology[MESH]|Pandemics[MESH]|Pneumonia, Viral/*immunology/*virology[MESH]|SARS-CoV-2[MESH]|Severe acute respiratory syndrome-related coronavirus/genetics/immunology[MESH]|Spike Glycoprotein, Coronavirus/genetics/metabolism[MESH]|Viral Proteins/*genetics/*metabolism[MESH]|Viral Structures/genetics[MESH]
  
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