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10.3390/cells9051127 http://scihub22266oqcxt.onion/10.3390/cells9051127 32370106!7291248!32370106     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32370106&cmd=llinks): Failed to open stream: HTTP request failed! 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Current Understanding of an Emerging Role of HLA-DRB1 Gene in Rheumatoid Arthritis-From Research to Clinical Practice |pdf=|usr=}}{{32370106}} gab.com Text Current Understanding of an Emerging Role of HLA-DRB1 Gene in Rheumatoid Arthritis-From Research to Clinical Practice JO: Cells http://www.kidney.de/pget.php?&tw=1&pmid=32370106 #FOAvip Rheumatoid arthritis (RA) is an autoimmune disease with an unclear pathogenic mechanism. However, it has been proven that the key underlying risk factor is a genetic predisposition. Association studies of the HLA-DRB1 gene clearly indicate its importance in RA morbidity. This review presents the current state of knowledge on the impact of HLA-DRB1 gene, functioning both as a component of the patient's genome and as an environmental risk factor. The impact of known HLA-DRB1 risk variants on the specific structure of the polymorphic HLA-DR molecule, and epitope binding affinity, is presented. The issues of the potential influence of HLA-DRB1 on the occurrence of non-articular disease manifestations and response to treatment are also discussed. A deeper understanding of the role of the HLA-DRB1 gene is essential to explore the complex nature of RA, which is a result of multiple contributing factors, including genetic, epigenetic and environmental factors. It also creates new opportunities to develop modern and personalized forms of therapy. Twit Text FOAVip Current Understanding of an Emerging Role of HLA-DRB1 Gene in Rheumatoid Arthritis-From Research to Clinical Practice ????Cells http://www.kidney.de/pget.php?&tw=1&pmid=32370106 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32370106 #FOAvip English Wikipedia <ref>{{Cite pmid|32370106}}</ref> Current Understanding of an Emerging Role of HLA-DRB1 Gene in Rheumatoid Arthritis-From Research to Clinical Practice #MMPMID32370106 Wysocki T; Olesinska M; Paradowska-Gorycka A Cells 2020[May]; 9 (5): ä PMID32370106show ga Rheumatoid arthritis (RA) is an autoimmune disease with an unclear pathogenic mechanism. However, it has been proven that the key underlying risk factor is a genetic predisposition. Association studies of the HLA-DRB1 gene clearly indicate its importance in RA morbidity. This review presents the current state of knowledge on the impact of HLA-DRB1 gene, functioning both as a component of the patient's genome and as an environmental risk factor. The impact of known HLA-DRB1 risk variants on the specific structure of the polymorphic HLA-DR molecule, and epitope binding affinity, is presented. The issues of the potential influence of HLA-DRB1 on the occurrence of non-articular disease manifestations and response to treatment are also discussed. A deeper understanding of the role of the HLA-DRB1 gene is essential to explore the complex nature of RA, which is a result of multiple contributing factors, including genetic, epigenetic and environmental factors. It also creates new opportunities to develop modern and personalized forms of therapy. |*Practice Patterns, Physicians'[MESH] |Anti-Citrullinated Protein Antibodies/immunology[MESH] |Arthritis, Rheumatoid/diagnosis/*genetics/immunology[MESH] |Epitopes/immunology[MESH] |Genetic Predisposition to Disease[MESH] |HLA-DRB1 Chains/*genetics[MESH]Current Understanding of an Emerging Role of HLA-DRB1 Gene in Rheumato(epmc).pdf DeepDyve Pubget Overpricing