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10.12122/j.issn.1673-4254.2020.02.02 http://scihub22266oqcxt.onion/10.12122/j.issn.1673-4254.2020.02.02 32376535!7086142!32376535     free     free     free Warning: Undefined variable $yww in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 538 Warning: Undefined variable $yww in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 538 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\32376535.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nan+Fang+Yi+Ke+Da+Xue+Xue+Bao 2020 ; 40 (2): 152-158 Nephropedia Template TP {{tp|p=32376535|t=2020. Analysis of variation and evolution of SARS-CoV-2 genome |pdf=|usr=}}{{32376535}} gab.com Text Analysis of variation and evolution of SARS-CoV-2 genome JO: Nan Fang Yi Ke Da Xue Xue Bao http://www.kidney.de/pget.php?&tw=1&pmid=32376535 #FOAvip OBJECTIVE: To analyze the evolution and variation of SARS-CoV-2 during the epidemic starting at the end of 2019. METHODS: We downloaded the full-length genome sequence of SARS-CoV-2 from the databases of GISAID and NCBI. Using the software for bioinformatics including MEGA-X, BEAST, and TempEst, we constructed the genomic evolution tree, inferred the time evolution signal of the virus, calculated the tMRCA time of the virus and analyzed the selection pressure of the virus during evolution. RESULTS: The phylogenetic tree showed that SARS-CoV-2 belonged to the Sarbecovirus subgenus of beta Coronavirus genus together with bat coronavirus BetaCoV/bat/Yunnan/RaTG13/2013, bat-SL-CoVZC45, bat-SL-CoVZXC21 and SARS-CoV. The genomic sequences of SARS-CoV-2 isolated from the ongoing epidemic showed a weak time evolution signal with an average tMRCA time of 73 days (95% CI: 38.9-119.3 days). No positive time evolution signal was found between SARS-CoV-2 and BetaCoV/bat/Yunnan/RaTG13/2013, but the former virus had a strong positive temporal evolution relationship with bat-SL-CoVZC45 and SARS-CoV. The major cause for mutations of SARS-CoV-2 was the pressure of purification selection during the epidemic. CONCLUSIONS: SARS-CoV-2 may have emerged as early as November, 2019, originating most likely from bat-associated coronavirus. This finding may provide evidence for tracing the sources and evolution of the virus. Twit Text FOAVip Analysis of variation and evolution of SARS-CoV-2 genome ????Nan Fang Yi Ke Da Xue Xue Bao http://www.kidney.de/pget.php?&tw=1&pmid=32376535 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32376535 #FOAvip English Wikipedia <ref>{{Cite pmid|32376535}}</ref> Analysis of variation and evolution of SARS-CoV-2 genome #MMPMID32376535 Zhou Y; Zhang S; Chen J; Wan C; Zhao W; Zhang B Nan Fang Yi Ke Da Xue Xue Bao 2020[Feb]; 40 (2): 152-158 PMID32376535show ga OBJECTIVE: To analyze the evolution and variation of SARS-CoV-2 during the epidemic starting at the end of 2019. METHODS: We downloaded the full-length genome sequence of SARS-CoV-2 from the databases of GISAID and NCBI. Using the software for bioinformatics including MEGA-X, BEAST, and TempEst, we constructed the genomic evolution tree, inferred the time evolution signal of the virus, calculated the tMRCA time of the virus and analyzed the selection pressure of the virus during evolution. RESULTS: The phylogenetic tree showed that SARS-CoV-2 belonged to the Sarbecovirus subgenus of beta Coronavirus genus together with bat coronavirus BetaCoV/bat/Yunnan/RaTG13/2013, bat-SL-CoVZC45, bat-SL-CoVZXC21 and SARS-CoV. The genomic sequences of SARS-CoV-2 isolated from the ongoing epidemic showed a weak time evolution signal with an average tMRCA time of 73 days (95% CI: 38.9-119.3 days). No positive time evolution signal was found between SARS-CoV-2 and BetaCoV/bat/Yunnan/RaTG13/2013, but the former virus had a strong positive temporal evolution relationship with bat-SL-CoVZC45 and SARS-CoV. The major cause for mutations of SARS-CoV-2 was the pressure of purification selection during the epidemic. CONCLUSIONS: SARS-CoV-2 may have emerged as early as November, 2019, originating most likely from bat-associated coronavirus. This finding may provide evidence for tracing the sources and evolution of the virus. |*Chiroptera/virology[MESH] |*Genome, Viral[MESH] |Animals[MESH] |Betacoronavirus/*genetics[MESH] |Biological Evolution[MESH] |COVID-19[MESH] |China[MESH] |Coronavirus Infections/genetics/*virology[MESH] |Coronavirus/genetics[MESH] |Pandemics[MESH] |Phylogeny[MESH] |Pneumonia, Viral/genetics/*virology[MESH] |SARS-CoV-2[MESH] Analysis of variation and evolution of SARS-CoV-2 genome (epmc).pdf DeepDyve Pubget Overpricing