
| 10.24875/AIDSRev.M20000030
http://scihub22266oqcxt.onion/10.24875/AIDSRev.M20000030
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AIDS+Rev 2020 ; 22 (2): 63-77 Nephropedia Template TP
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COVID-19 Comes 40 Years After AIDS - Any Lesson? #MMPMID32412509Soriano V; Barreiro P; Ramos JM; Eiros JM; de Mendoza CAIDS Rev 2020[Jul]; 22 (2): 63-77 PMID32412509show ga
The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has hit health-care systems and societies in an unprecedented manner. In 1981, the first cases of AIDS were reported and wide diagnostic testing helped to characterize high-risk groups and the global burden of the epidemic. With Coronavirus Disease (COVID)-19, everything has happened too fast and both cases and fatalities are huge but still uncertain in most places. Diagnostic testing of active and past SARS-CoV-2 infections needs to expand rapidly, ideally using rapid tests. COVID-19 deaths are highly concentrated in the elderly population, with a large proportion of fatalities being "with" rather than "by" SARS-CoV-2 infection. They are often the result of inadequate health care due to overwhelming demands. To date, there is no specific therapy for SARS-CoV-2 infection. Several antivirals are being tested clinically, including remdesivir, at this time the most promising. For others such as lopinavir/ritonavir, neither significant virological nor clinical benefit has been shown. Given the characteristic pulmonary cytokine storm underlying the pathogenic mechanism of severe COVID-19 pneumonia and acute respiratory distress, antiinflammatory agents are being investigated. The benefit of orticosteroids, hydroxychloroquine, etc., is limited. Monoclonal antibodies targeting different pro-inflammatory cytokines, such as tocilizumab, an anti-interleukin 6 agent, are being tried with encouraging results. Ultimately a protective vaccine will be the best response for controlling the COVID-19 pandemic.|Acquired Immunodeficiency Syndrome/*epidemiology[MESH]|Betacoronavirus/genetics/pathogenicity[MESH]|COVID-19[MESH]|Communicable Disease Control[MESH]|Coronavirus Infections/*epidemiology/immunology/therapy/transmission[MESH]|Cytokine Release Syndrome/immunology[MESH]|HIV Infections/epidemiology[MESH]|Humans[MESH]|Pandemics[MESH]|Pneumonia, Viral/*epidemiology/immunology/therapy/transmission[MESH]|SARS-CoV-2[MESH]|Severity of Illness Index[MESH]
  
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