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10.1038/s41588-020-0625-2 http://scihub22266oqcxt.onion/10.1038/s41588-020-0625-2 32424349!7276299!32424349     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32424349&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\32424349.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Genet 2020 ; 52 (6): 626-633 Nephropedia Template TP {{tp|p=32424349|t=2020. Quantifying genetic effects on disease mediated by assayed gene expression levels |pdf=|usr=}}{{32424349}} gab.com Text Quantifying genetic effects on disease mediated by assayed gene expression levels JO: Nat Genet http://www.kidney.de/pget.php?&tw=1&pmid=32424349 #FOAvip Disease variants identified by genome-wide association studies (GWAS) tend to overlap with expression quantitative trait loci (eQTLs), but it remains unclear whether this overlap is driven by gene expression levels 'mediating' genetic effects on disease. Here, we introduce a new method, mediated expression score regression (MESC), to estimate disease heritability mediated by the cis genetic component of gene expression levels. We applied MESC to GWAS summary statistics for 42 traits (average N = 323,000) and cis-eQTL summary statistics for 48 tissues from the Genotype-Tissue Expression (GTEx) consortium. Averaging across traits, only 11 +/- 2% of heritability was mediated by assayed gene expression levels. Expression-mediated heritability was enriched in genes with evidence of selective constraint and genes with disease-appropriate annotations. Our results demonstrate that assayed bulk tissue eQTLs, although disease relevant, cannot explain the majority of disease heritability. Twit Text FOAVip Quantifying genetic effects on disease mediated by assayed gene expression levels ????Nat Genet http://www.kidney.de/pget.php?&tw=1&pmid=32424349 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32424349 #FOAvip English Wikipedia <ref>{{Cite pmid|32424349}}</ref> Quantifying genetic effects on disease mediated by assayed gene expression levels #MMPMID32424349 Yao DW; O'Connor LJ; Price AL; Gusev A Nat Genet 2020[Jun]; 52 (6): 626-633 PMID32424349show ga Disease variants identified by genome-wide association studies (GWAS) tend to overlap with expression quantitative trait loci (eQTLs), but it remains unclear whether this overlap is driven by gene expression levels 'mediating' genetic effects on disease. Here, we introduce a new method, mediated expression score regression (MESC), to estimate disease heritability mediated by the cis genetic component of gene expression levels. We applied MESC to GWAS summary statistics for 42 traits (average N = 323,000) and cis-eQTL summary statistics for 48 tissues from the Genotype-Tissue Expression (GTEx) consortium. Averaging across traits, only 11 +/- 2% of heritability was mediated by assayed gene expression levels. Expression-mediated heritability was enriched in genes with evidence of selective constraint and genes with disease-appropriate annotations. Our results demonstrate that assayed bulk tissue eQTLs, although disease relevant, cannot explain the majority of disease heritability. |*Gene Expression[MESH] |*Genetic Predisposition to Disease[MESH] |*Quantitative Trait Loci[MESH] |Calibration[MESH] |Genome-Wide Association Study/methods/*statistics & numerical data[MESH] |Humans[MESH] |Linkage Disequilibrium[MESH] |Polymorphism, Single Nucleotide[MESH]Quantifying genetic effects on disease mediated by assayed gene expres(epmc).pdf DeepDyve Pubget Overpricing