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10.1177/1753466620926800 http://scihub22266oqcxt.onion/10.1177/1753466620926800 32436460!7243041!32436460     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32436460&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\32436460.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Ther+Adv+Respir+Dis 2020 ; 14 (ä): 1753466620926800 Nephropedia Template TP {{tp|p=32436460|t=2020. TNFalpha inhibitor may be effective for severe COVID-19: learning from toxic epidermal necrolysis |pdf=|usr=}}{{32436460}} gab.com Text TNFalpha inhibitor may be effective for severe COVID-19: learning from toxic epidermal necrolysis JO: Ther Adv Respir Dis http://www.kidney.de/pget.php?&tw=1&pmid=32436460 #FOAvip Increased inflammatory cytokines [such as tumor necrosis factor alpha (TNFalpha) and interleukin-6 (IL-6)] are observed in COVID-19 patients, especially in the severe group. The phenomenon of a cytokine storm may be the central inducer of apoptosis of alveolar epithelial cells, which leads to rapid progression in severe group patients. Given the similarities of clinical features and pathogenesis between toxic epidermal necrolysis (TEN) and COVID-19, we hypothesize that the application of etanercept, an inhibitor of TNFalpha, could attenuate disease progression in severe group COVID-19 patients by suppressing systemic auto-inflammatory responses. The reviews of this paper are available via the supplemental material section. Twit Text FOAVip TNFalpha inhibitor may be effective for severe COVID-19: learning from toxic epidermal necrolysis ????Ther Adv Respir Dis http://www.kidney.de/pget.php?&tw=1&pmid=32436460 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32436460 #FOAvip English Wikipedia <ref>{{Cite pmid|32436460}}</ref> TNFalpha inhibitor may be effective for severe COVID-19: learning from toxic epidermal necrolysis #MMPMID32436460 Chen XY; Yan BX; Man XY Ther Adv Respir Dis 2020[Jan]; 14 (ä): 1753466620926800 PMID32436460show ga Increased inflammatory cytokines [such as tumor necrosis factor alpha (TNFalpha) and interleukin-6 (IL-6)] are observed in COVID-19 patients, especially in the severe group. The phenomenon of a cytokine storm may be the central inducer of apoptosis of alveolar epithelial cells, which leads to rapid progression in severe group patients. Given the similarities of clinical features and pathogenesis between toxic epidermal necrolysis (TEN) and COVID-19, we hypothesize that the application of etanercept, an inhibitor of TNFalpha, could attenuate disease progression in severe group COVID-19 patients by suppressing systemic auto-inflammatory responses. The reviews of this paper are available via the supplemental material section. |Betacoronavirus/immunology[MESH] |COVID-19[MESH] |Coronavirus Infections/*complications/*drug therapy[MESH] |Cytokine Release Syndrome/drug therapy/*etiology/physiopathology[MESH] |Etanercept/*therapeutic use[MESH] |Humans[MESH] |Pandemics[MESH] |Pneumonia, Viral/*complications/*drug therapy[MESH] |SARS-CoV-2[MESH] |Stevens-Johnson Syndrome/*drug therapy[MESH] |Tumor Necrosis Factor Inhibitors/*therapeutic use[MESH]TNFalpha inhibitor may be effective for severe COVID-19: learning from(epmc).pdf DeepDyve Pubget Overpricing