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10.1016/j.bbrc.2020.04.007 http://scihub22266oqcxt.onion/10.1016/j.bbrc.2020.04.007 32451080!7144664!32451080     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\32451080.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Biochem+Biophys+Res+Commun 2020 ; 528 (1): 35-38 Nephropedia Template TP {{tp|p=32451080|t=2020. A possible strategy to fight COVID-19: Interfering with spike glycoprotein trimerization |pdf=|usr=}}{{32451080}} gab.com Text A possible strategy to fight COVID-19: Interfering with spike glycoprotein trimerization JO: Biochem Biophys Res Commun http://www.kidney.de/pget.php?&tw=1&pmid=32451080 #FOAvip The recent release of COVID-19 spike glycoprotein allows detailed analysis of the structural features that are required for stabilizing the infective form of its quaternary assembly. Trying to disassemble the trimeric structure of COVID-19 spike glycoprotein, we analyzed single protomer surfaces searching for concave moieties that are located at the three protomer-protomer interfaces. The presence of some druggable pockets at these interfaces suggested that some of the available drugs in Drug Bank could destabilize the quaternary spike glycoprotein formation by binding to these pockets, therefore interfering with COVID-19 life cycle. The approach we propose here can be an additional strategy to fight against the deadly virus. Ligands of COVID-19 spike glycoprotein that we have predicted in the present computational investigation, might be the basis for new experimental studies in vitro and in vivo. Twit Text FOAVip A possible strategy to fight COVID-19: Interfering with spike glycoprotein trimerization ????Biochem Biophys Res Commun http://www.kidney.de/pget.php?&tw=1&pmid=32451080 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32451080 #FOAvip English Wikipedia <ref>{{Cite pmid|32451080}}</ref> A possible strategy to fight COVID-19: Interfering with spike glycoprotein trimerization #MMPMID32451080 Bongini P; Trezza A; Bianchini M; Spiga O; Niccolai N Biochem Biophys Res Commun 2020[Jul]; 528 (1): 35-38 PMID32451080show ga The recent release of COVID-19 spike glycoprotein allows detailed analysis of the structural features that are required for stabilizing the infective form of its quaternary assembly. Trying to disassemble the trimeric structure of COVID-19 spike glycoprotein, we analyzed single protomer surfaces searching for concave moieties that are located at the three protomer-protomer interfaces. The presence of some druggable pockets at these interfaces suggested that some of the available drugs in Drug Bank could destabilize the quaternary spike glycoprotein formation by binding to these pockets, therefore interfering with COVID-19 life cycle. The approach we propose here can be an additional strategy to fight against the deadly virus. Ligands of COVID-19 spike glycoprotein that we have predicted in the present computational investigation, might be the basis for new experimental studies in vitro and in vivo. |*Drug Evaluation, Preclinical[MESH] |Amino Acid Sequence[MESH] |Antiviral Agents/chemistry/pharmacology/therapeutic use[MESH] |Betacoronavirus/chemistry/*drug effects/physiology[MESH] |Binding Sites[MESH] |COVID-19[MESH] |Coronavirus Infections/*drug therapy/epidemiology[MESH] |Ligands[MESH] |Models, Molecular[MESH] |Pandemics[MESH] |Pneumonia, Viral/*drug therapy/epidemiology[MESH] |Protein Multimerization/*drug effects[MESH] |SARS-CoV-2[MESH] |Small Molecule Libraries/chemistry/*pharmacology/therapeutic use[MESH]A possible strategy to fight COVID-19: Interfering with spike glycopro(epmc).pdf DeepDyve Pubget Overpricing