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10.1111/1440-1681.13354 http://scihub22266oqcxt.onion/10.1111/1440-1681.13354 32459003!ä!32459003 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\32459003.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Clin+Exp+Pharmacol+Physiol 2020 ; 47 (10): 1765-1767 Nephropedia Template TP {{tp|p=32459003|t=2020. A role for retinoids in the treatment of COVID-19?|pdf=|usr=}}{{32459003}} gab.com Text A role for retinoids in the treatment of COVID-19 JO: Clin Exp Pharmacol Physiol http://www.kidney.de/pget.php?&tw=1&pmid=32459003 #FOAvip The 2020 global outbreak of the novel coronavirus (SARS-CoV-2 or COVID-19) is a serious threat to international health, and thus, there is an urgent need for discovery of novel therapies or use of repurposed drugs that can make a significant impact on slowing the spread of the virus. Type 1 interferons (IFN-I) are a family cytokines of the early innate immune response to viruses that are being tested against SARS-CoV-2. However, coronaviruses similar to SARS-CoV-2 can suppress host IFN-I antiviral responses. Retinoids are a family molecules related to vitamin A that possess robust immune-modulating properties, including the ability to increase and potentiate the actions of IFN-I. Therefore, adjuvants such as retinoids, capable of increasing IFN-I-mediated antiviral responses, should be tested in combinations of IFN-I and antiviral drugs in pre-clinical studies of SARS-CoV-2. Twit Text FOAVip A role for retinoids in the treatment of COVID-19 ????Clin Exp Pharmacol Physiol http://www.kidney.de/pget.php?&tw=1&pmid=32459003 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32459003 #FOAvip English Wikipedia <ref>{{Cite pmid|32459003}}</ref> A role for retinoids in the treatment of COVID-19? #MMPMID32459003 Trasino SE Clin Exp Pharmacol Physiol 2020[Oct]; 47 (10): 1765-1767 PMID32459003show ga The 2020 global outbreak of the novel coronavirus (SARS-CoV-2 or COVID-19) is a serious threat to international health, and thus, there is an urgent need for discovery of novel therapies or use of repurposed drugs that can make a significant impact on slowing the spread of the virus. Type 1 interferons (IFN-I) are a family cytokines of the early innate immune response to viruses that are being tested against SARS-CoV-2. However, coronaviruses similar to SARS-CoV-2 can suppress host IFN-I antiviral responses. Retinoids are a family molecules related to vitamin A that possess robust immune-modulating properties, including the ability to increase and potentiate the actions of IFN-I. Therefore, adjuvants such as retinoids, capable of increasing IFN-I-mediated antiviral responses, should be tested in combinations of IFN-I and antiviral drugs in pre-clinical studies of SARS-CoV-2. |*Betacoronavirus/drug effects[MESH] |Antiviral Agents/pharmacology/*therapeutic use[MESH] |COVID-19[MESH] |Clinical Trials as Topic/methods[MESH] |Coronavirus Infections/diagnosis/*drug therapy[MESH] |Humans[MESH] |Immunologic Factors/pharmacology/therapeutic use[MESH] |Interferon Type I/pharmacology/therapeutic use[MESH] |Pandemics[MESH] |Pneumonia, Viral/diagnosis/*drug therapy[MESH] |Retinoids/pharmacology/*therapeutic use[MESH] |SARS-CoV-2[MESH]A role for retinoids in the treatment of COVID-19?(epmc).pdf DeepDyve Pubget Overpricing