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10.1152/ajprenal.00125.2020 http://scihub22266oqcxt.onion/10.1152/ajprenal.00125.2020 32463726!7468826!32463726     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32463726&cmd=llinks): Failed to open stream: HTTP request failed! 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Differential effects of low-dose sacubitril and/or valsartan on renal disease in salt-sensitive hypertension |pdf=|usr=}}{{32463726}} gab.com Text Differential effects of low-dose sacubitril and/or valsartan on renal disease in salt-sensitive hypertension JO: Am J Physiol Renal Physiol http://www.kidney.de/pget.php?&tw=1&pmid=32463726 #FOAvip Diuretics and renin-angiotensin system blockers are often insufficient to control the blood pressure (BP) in salt-sensitive (SS) subjects. Abundant data support the proposal that the level of atrial natriuretic peptide may correlate with the pathogenesis of SS hypertension. We hypothesized here that increasing atrial natriuretic peptide levels with sacubitril, combined with renin-angiotensin system blockage by valsartan, can be beneficial for alleviation of renal damage in a model of SS hypertension, the Dahl SS rat. To induce a BP increase, rats were challenged with a high-salt 4% NaCl diet for 21 days, and chronic administration of vehicle or low-dose sacubitril and/or valsartan (75 mug/day each) was performed. Urine flow, Na(+) excretion, and water consumption were increased on the high-salt diet compared with the starting point (0.4% NaCl) in all groups but remained similar among the groups at the end of the protocol. Upon salt challenge, we observed a mild decrease in systolic BP and urinary neutrophil gelatinase-associated lipocalin levels (indicative of alleviated tubular damage) in the valsartan-treated groups. Sacubitril, as well as sacubitril/valsartan, attenuated the glomerular filtration rate decline induced by salt. Alleviation of protein cast formation and lower renal medullary fibrosis were observed in the sacubitril/valsartan- and valsartan-treated groups, but not when sacubitril alone was administered. Interestingly, proteinuria was mildly mitigated only in rats that received sacubitril/valsartan. Further studies of the effects of sacubitril/valsartan in the setting of SS hypertension, perhaps involving a higher dose of the drug, are warranted to determine if it can interfere with the progression of the disease. Twit Text FOAVip Differential effects of low-dose sacubitril and/or valsartan on renal disease in salt-sensitive hypertension ????Am J Physiol Renal Physiol http://www.kidney.de/pget.php?&tw=1&pmid=32463726 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32463726 #FOAvip English Wikipedia <ref>{{Cite pmid|32463726}}</ref> Differential effects of low-dose sacubitril and/or valsartan on renal disease in salt-sensitive hypertension #MMPMID32463726 Polina I; Domondon M; Fox R; Sudarikova AV; Troncoso M; Vasileva VY; Kashyrina Y; Gooz MB; Schibalski RS; DeLeon-Pennell KY; Fitzgibbon WR; Ilatovskaya DV Am J Physiol Renal Physiol 2020[Jul]; 319 (1): F63-F75 PMID32463726show ga Diuretics and renin-angiotensin system blockers are often insufficient to control the blood pressure (BP) in salt-sensitive (SS) subjects. Abundant data support the proposal that the level of atrial natriuretic peptide may correlate with the pathogenesis of SS hypertension. We hypothesized here that increasing atrial natriuretic peptide levels with sacubitril, combined with renin-angiotensin system blockage by valsartan, can be beneficial for alleviation of renal damage in a model of SS hypertension, the Dahl SS rat. To induce a BP increase, rats were challenged with a high-salt 4% NaCl diet for 21 days, and chronic administration of vehicle or low-dose sacubitril and/or valsartan (75 mug/day each) was performed. Urine flow, Na(+) excretion, and water consumption were increased on the high-salt diet compared with the starting point (0.4% NaCl) in all groups but remained similar among the groups at the end of the protocol. Upon salt challenge, we observed a mild decrease in systolic BP and urinary neutrophil gelatinase-associated lipocalin levels (indicative of alleviated tubular damage) in the valsartan-treated groups. Sacubitril, as well as sacubitril/valsartan, attenuated the glomerular filtration rate decline induced by salt. Alleviation of protein cast formation and lower renal medullary fibrosis were observed in the sacubitril/valsartan- and valsartan-treated groups, but not when sacubitril alone was administered. Interestingly, proteinuria was mildly mitigated only in rats that received sacubitril/valsartan. Further studies of the effects of sacubitril/valsartan in the setting of SS hypertension, perhaps involving a higher dose of the drug, are warranted to determine if it can interfere with the progression of the disease. |Aminobutyrates/*administration & dosage/therapeutic use[MESH] |Angiotensin Receptor Antagonists/*administration & dosage/therapeutic use[MESH] |Animals[MESH] |Biphenyl Compounds[MESH] |Blood Pressure/*drug effects[MESH] |Drug Combinations[MESH] |Hypertension/*drug therapy/physiopathology[MESH] |Kidney Diseases/*drug therapy/physiopathology[MESH] |Male[MESH] |Rats[MESH] |Rats, Inbred Dahl[MESH] |Sodium Chloride, Dietary[MESH] |Tetrazoles/*administration & dosage/therapeutic use[MESH]Differential effects of low-dose sacubitril and/or valsartan on renal (epmc).pdf DeepDyve Pubget Overpricing