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10.1007/s11095-020-02844-6 http://scihub22266oqcxt.onion/10.1007/s11095-020-02844-6 32488611!7266419!32488611     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32488611&cmd=llinks): Failed to open stream: HTTP request failed! 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Microneedle Mediated Transdermal Delivery of Protein, Peptide and Antibody Based Therapeutics: Current Status and Future Considerations |pdf=|usr=}}{{32488611}} gab.com Text Microneedle Mediated Transdermal Delivery of Protein, Peptide and Antibody Based Therapeutics: Current Status and Future Considerations JO: Pharm Res http://www.kidney.de/pget.php?&tw=1&pmid=32488611 #FOAvip The success of protein, peptide and antibody based therapies is evident - the biopharmaceuticals market is predicted to reach $388 billion by 2024 [1], and more than half of the current top 20 blockbuster drugs are biopharmaceuticals. However, the intrinsic properties of biopharmaceuticals has restricted the routes available for successful drug delivery. While providing 100% bioavailability, the intravenous route is often associated with pain and needle phobia from a patient perspective, which may translate as a reluctance to receive necessary treatment. Several non-invasive strategies have since emerged to overcome these limitations. One such strategy involves the use of microneedles (MNs), which are able to painlessly penetrate the stratum corneum barrier to dramatically increase transdermal drug delivery of numerous drugs. This review reports the wealth of studies that aim to enhance transdermal delivery of biopharmaceutics using MNs. The true potential of MNs as a drug delivery device for biopharmaceuticals will not only rely on acceptance from prescribers, patients and the regulatory authorities, but the ability to upscale MN manufacture in a cost-effective manner and the long term safety of MN application. Thus, the current barriers to clinical translation of MNs, and how these barriers may be overcome are also discussed. Twit Text FOAVip Microneedle Mediated Transdermal Delivery of Protein, Peptide and Antibody Based Therapeutics: Current Status and Future Considerations ????Pharm Res http://www.kidney.de/pget.php?&tw=1&pmid=32488611 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32488611 #FOAvip English Wikipedia <ref>{{Cite pmid|32488611}}</ref> Microneedle Mediated Transdermal Delivery of Protein, Peptide and Antibody Based Therapeutics: Current Status and Future Considerations #MMPMID32488611 Kirkby M; Hutton ARJ; Donnelly RF Pharm Res 2020[Jun]; 37 (6): 117 PMID32488611show ga The success of protein, peptide and antibody based therapies is evident - the biopharmaceuticals market is predicted to reach $388 billion by 2024 [1], and more than half of the current top 20 blockbuster drugs are biopharmaceuticals. However, the intrinsic properties of biopharmaceuticals has restricted the routes available for successful drug delivery. While providing 100% bioavailability, the intravenous route is often associated with pain and needle phobia from a patient perspective, which may translate as a reluctance to receive necessary treatment. Several non-invasive strategies have since emerged to overcome these limitations. One such strategy involves the use of microneedles (MNs), which are able to painlessly penetrate the stratum corneum barrier to dramatically increase transdermal drug delivery of numerous drugs. This review reports the wealth of studies that aim to enhance transdermal delivery of biopharmaceutics using MNs. The true potential of MNs as a drug delivery device for biopharmaceuticals will not only rely on acceptance from prescribers, patients and the regulatory authorities, but the ability to upscale MN manufacture in a cost-effective manner and the long term safety of MN application. Thus, the current barriers to clinical translation of MNs, and how these barriers may be overcome are also discussed. |Administration, Cutaneous[MESH] |Animals[MESH] |Antibodies/administration & dosage[MESH] |Drug Delivery Systems/*instrumentation/methods/*trends[MESH] |Epidermis[MESH] |Humans[MESH] |Microinjections/*instrumentation/methods/*trends[MESH] |Needles[MESH] |Peptides/administration & dosage[MESH] |Pharmaceutical Preparations/*administration & dosage[MESH] |Proteins/administration & dosage[MESH]Microneedle Mediated Transdermal Delivery of Protein, Peptide and Anti(epmc).pdf DeepDyve Pubget Overpricing