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10.1016/j.ad.2020.05.001 http://scihub22266oqcxt.onion/10.1016/j.ad.2020.05.001 32513393!7211725!32513393     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32513393&cmd=llinks): Failed to open stream: HTTP request failed! 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Estimacion del efecto en el tamano y la supervivencia de los tumores cutaneos debido al confinamiento por COVID-19: modelo basado en un crecimiento exponencial |pdf=|usr=}}{{32513393}} gab.com Text Estimacion del efecto en el tamano y la supervivencia de los tumores cutaneos debido al confinamiento por COVID-19: modelo basado en un crecimiento exponencial JO: Actas Dermosifiliogr (Engl Ed) http://www.kidney.de/pget.php?&tw=1&pmid=32513393 #FOAvip BACKGROUND AND OBJECTIVES: Spain is in a situation of indefinite lockdown due to the ongoing coronavirus disease 2019 (COVID-19) pandemic. One of the consequences of this lockdown is delays in medical and surgical procedures for common diseases. The aim of this study was to model the impact on survival of tumor growth caused by such delays in patients with squamous cell carcinoma (SCC) and melanoma. MATERIAL AND METHODS: Multicenter, retrospective, observational cohort study. We constructed an exponential growth model for both SCC and melanoma to estimate tumor growth between patient-reported onset and surgical excision at different time points. RESULTS: Data from 200 patients with SCC of the head and neck and 1000 patients with cutaneous melanoma were included. An exponential growth curve was calculated for each tumor type and we estimated tumor size after 1, 2, and 3 months of potential surgical delay. The proportion of patients with T3 SCC (diameter >4cm or thickness >6 mm) increased from 41.5% (83 patients) in the initial study group to an estimated 58.5%, 70.5%, and 72% after 1, 2, and 3 months of delay. Disease-specific survival at 2, 5, and 10 years in patients whose surgery was delayed by 3 months decreased by 6.2%, 8.2%, and 5.2%, respectively. The proportion of patients with ultrathick melanoma (>6 mm) increased from 6.9% in the initial study group to 21.9%, 30.2%, and 30.2% at 1, 2, and 3 months. Five- and 10-year disease-specific survival both decreased by 14.4% in patients treated after a potential delay of 3 months. CONCLUSIONS: In the absence of adequate diagnosis and treatment of SCC and melanoma in the current lockdown situation in Spain, we can expect to see to a considerable increase in large and thick SCCs and melanomas. Efforts must be taken to encourage self-examination and facilitate access to dermatologists in order to prevent further delays. Twit Text FOAVip Estimacion del efecto en el tamano y la supervivencia de los tumores cutaneos debido al confinamiento por COVID-19: modelo basado en un crecimiento exponencial ????Actas Dermosifiliogr (Engl Ed) http://www.kidney.de/pget.php?&tw=1&pmid=32513393 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32513393 #FOAvip English Wikipedia <ref>{{Cite pmid|32513393}}</ref> Estimacion del efecto en el tamano y la supervivencia de los tumores cutaneos debido al confinamiento por COVID-19: modelo basado en un crecimiento exponencial #MMPMID32513393 Tejera-Vaquerizo A; Canueto J; Toll A; Santos-Juanes J; Jaka A; Ferrandiz-Pulido C; Sanmartin O; Ribero S; Moreno-Ramirez D; Almazan F; Fuente MJ; Podlipnik S; Nagore E Actas Dermosifiliogr (Engl Ed) 2020[Oct]; 111 (8): 629-638 PMID32513393show ga BACKGROUND AND OBJECTIVES: Spain is in a situation of indefinite lockdown due to the ongoing coronavirus disease 2019 (COVID-19) pandemic. One of the consequences of this lockdown is delays in medical and surgical procedures for common diseases. The aim of this study was to model the impact on survival of tumor growth caused by such delays in patients with squamous cell carcinoma (SCC) and melanoma. MATERIAL AND METHODS: Multicenter, retrospective, observational cohort study. We constructed an exponential growth model for both SCC and melanoma to estimate tumor growth between patient-reported onset and surgical excision at different time points. RESULTS: Data from 200 patients with SCC of the head and neck and 1000 patients with cutaneous melanoma were included. An exponential growth curve was calculated for each tumor type and we estimated tumor size after 1, 2, and 3 months of potential surgical delay. The proportion of patients with T3 SCC (diameter >4cm or thickness >6 mm) increased from 41.5% (83 patients) in the initial study group to an estimated 58.5%, 70.5%, and 72% after 1, 2, and 3 months of delay. Disease-specific survival at 2, 5, and 10 years in patients whose surgery was delayed by 3 months decreased by 6.2%, 8.2%, and 5.2%, respectively. The proportion of patients with ultrathick melanoma (>6 mm) increased from 6.9% in the initial study group to 21.9%, 30.2%, and 30.2% at 1, 2, and 3 months. Five- and 10-year disease-specific survival both decreased by 14.4% in patients treated after a potential delay of 3 months. CONCLUSIONS: In the absence of adequate diagnosis and treatment of SCC and melanoma in the current lockdown situation in Spain, we can expect to see to a considerable increase in large and thick SCCs and melanomas. Efforts must be taken to encourage self-examination and facilitate access to dermatologists in order to prevent further delays. |*Betacoronavirus[MESH] |*Tumor Burden[MESH] |Age Factors[MESH] |Algorithms[MESH] |COVID-19[MESH] |Carcinoma, Squamous Cell/mortality/*pathology[MESH] |Coronavirus Infections/*epidemiology[MESH] |Delayed Diagnosis/adverse effects/statistics & numerical data[MESH] |Female[MESH] |Head and Neck Neoplasms/mortality/*pathology[MESH] |Health Services Accessibility[MESH] |Humans[MESH] |Male[MESH] |Melanoma/mortality/*pathology[MESH] |Pandemics[MESH] |Pneumonia, Viral/*epidemiology[MESH] |Public Health Surveillance/methods[MESH] |Quarantine[MESH] |Retrospective Studies[MESH] |SARS-CoV-2[MESH] |Sex Factors[MESH] |Skin Neoplasms/mortality/*pathology[MESH] |Spain/epidemiology[MESH] |Time Factors[MESH]Estimacion del efecto en el tamano y la supervivencia de los tumores c(epmc).pdf DeepDyve Pubget Overpricing