
| 10.1016/j.cytogfr.2020.06.001
http://scihub22266oqcxt.onion/10.1016/j.cytogfr.2020.06.001
 32513566!7265853!32513566
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Cytokine+Growth+Factor+Rev 2020 ; 54 (�): 62-75 Nephropedia Template TP
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SARS-CoV-2 infection: The role of cytokines in COVID-19 disease #MMPMID32513566Costela-Ruiz VJ; Illescas-Montes R; Puerta-Puerta JM; Ruiz C; Melguizo-Rodriguez LCytokine Growth Factor Rev 2020[Aug]; 54 (�): 62-75 PMID32513566show ga
COVID-19 disease, caused by infection with SARS-CoV-2, is related to a series of physiopathological mechanisms that mobilize a wide variety of biomolecules, mainly immunological in nature. In the most severe cases, the prognosis can be markedly worsened by the hyperproduction of mainly proinflammatory cytokines, such as IL-1, IL-6, IL-12, IFN-gamma, and TNF-alpha, preferentially targeting lung tissue. This study reviews published data on alterations in the expression of different cytokines in patients with COVID-19 who require admission to an intensive care unit. Data on the implication of cytokines in this disease and their effect on outcomes will support the design of more effective approaches to the management of COVID-19.|Betacoronavirus/*immunology[MESH]|COVID-19[MESH]|Coronavirus Infections/immunology/mortality/*pathology[MESH]|Cytokine Release Syndrome/immunology/*pathology[MESH]|Cytokines/*metabolism[MESH]|Humans[MESH]|Pandemics[MESH]|Pneumonia, Viral/immunology/mortality/*pathology[MESH]|SARS-CoV-2[MESH]
  
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