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10.1093/infdis/jiaa332 http://scihub22266oqcxt.onion/10.1093/infdis/jiaa332 32526012!7377288!32526012     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\32526012.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Infect+Dis 2020 ; 222 (4): 556-563 Nephropedia Template TP {{tp|p=32526012|t=2020. ACE2 Expression Is Increased in the Lungs of Patients With Comorbidities Associated With Severe COVID-19 |pdf=|usr=}}{{32526012}} gab.com Text ACE2 Expression Is Increased in the Lungs of Patients With Comorbidities Associated With Severe COVID-19 JO: J Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=32526012 #FOAvip Patients who died from COVID-19 often had comorbidities, such as hypertension, diabetes, and chronic obstructive lung disease. Although angiotensin-converting enzyme 2 (ACE2) is crucial for SARS-CoV-2 to bind and enter host cells, no study has systematically assessed the ACE2 expression in the lungs of patients with these diseases. Here, we analyzed over 700 lung transcriptome samples from patients with comorbidities associated with severe COVID-19 and found that ACE2 was highly expressed in these patients compared to control individuals. This finding suggests that patients with such comorbidities may have higher chances of developing severe COVID-19. Correlation and network analyses revealed many potential regulators of ACE2 in the human lung, including genes related to histone modifications, such as HAT1, HDAC2, and KDM5B. Our systems biology approach offers a possible explanation for increased COVID-19 severity in patients with certain comorbidities. Twit Text FOAVip ACE2 Expression Is Increased in the Lungs of Patients With Comorbidities Associated With Severe COVID-19 ????J Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=32526012 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32526012 #FOAvip English Wikipedia <ref>{{Cite pmid|32526012}}</ref> ACE2 Expression Is Increased in the Lungs of Patients With Comorbidities Associated With Severe COVID-19 #MMPMID32526012 Pinto BGG; Oliveira AER; Singh Y; Jimenez L; Goncalves ANA; Ogava RLT; Creighton R; Schatzmann Peron JP; Nakaya HI J Infect Dis 2020[Jul]; 222 (4): 556-563 PMID32526012show ga Patients who died from COVID-19 often had comorbidities, such as hypertension, diabetes, and chronic obstructive lung disease. Although angiotensin-converting enzyme 2 (ACE2) is crucial for SARS-CoV-2 to bind and enter host cells, no study has systematically assessed the ACE2 expression in the lungs of patients with these diseases. Here, we analyzed over 700 lung transcriptome samples from patients with comorbidities associated with severe COVID-19 and found that ACE2 was highly expressed in these patients compared to control individuals. This finding suggests that patients with such comorbidities may have higher chances of developing severe COVID-19. Correlation and network analyses revealed many potential regulators of ACE2 in the human lung, including genes related to histone modifications, such as HAT1, HDAC2, and KDM5B. Our systems biology approach offers a possible explanation for increased COVID-19 severity in patients with certain comorbidities. |Angiotensin-Converting Enzyme 2[MESH] |COVID-19[MESH] |Case-Control Studies[MESH] |Cerebrovascular Disorders/epidemiology/genetics[MESH] |Comorbidity[MESH] |Coronary Disease/epidemiology/genetics[MESH] |Coronavirus Infections/enzymology/*epidemiology/genetics[MESH] |Diabetes Complications/epidemiology/genetics[MESH] |Epigenomics[MESH] |Female[MESH] |Humans[MESH] |Hypertension/epidemiology/genetics[MESH] |Lung/*enzymology[MESH] |Male[MESH] |Pandemics[MESH] |Peptidyl-Dipeptidase A/genetics/*metabolism[MESH] |Pneumonia, Viral/enzymology/*epidemiology/genetics[MESH] |Pulmonary Disease, Chronic Obstructive/epidemiology/genetics[MESH] |Severity of Illness Index[MESH] |Systems Biology[MESH]ACE2 Expression Is Increased in the Lungs of Patients With Comorbiditi(epmc).pdf DeepDyve Pubget Overpricing