
| 10.1136/annrheumdis-2020-217763
http://scihub22266oqcxt.onion/10.1136/annrheumdis-2020-217763
 32532753!7299645!32532753
free
free
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Ann+Rheum+Dis 2020 ; 79 (9): 1170-1173 Nephropedia Template TP
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Prevalence of hospital PCR-confirmed COVID-19 cases in patients with chronic inflammatory and autoimmune rheumatic diseases #MMPMID32532753Pablos JL; Abasolo L; Alvaro-Gracia JM; Blanco FJ; Blanco R; Castrejon I; Fernandez-Fernandez D; Fernandez-Gutierrez B; Galindo-Izquierdo M; Gonzalez-Gay MA; Manrique-Arija S; Mena Vazquez N; Mera Varela A; Retuerto M; Seijas-Lopez AAnn Rheum Dis 2020[Sep]; 79 (9): 1170-1173 PMID32532753show ga
BACKGROUND: The susceptibility of patients with rheumatic diseases and the risks or benefits of immunosuppressive therapies for COVID-19 are unknown. METHODS: We performed a retrospective study with patients under follow-up in rheumatology departments from seven hospitals in Spain. We matched updated databases of rheumatology patients with severe acute respiratory syndrome coronavirus 2-positive PCR tests performed in the hospital to the same reference populations. Rates of PCR+ confirmed COVID-19 were compared among groups. RESULTS: Patients with chronic inflammatory diseases had 1.32-fold higher prevalence of hospital PCR+ COVID-19 than the reference population (0.76% vs 0.58%). Patients with systemic autoimmune or immune-mediated disease (AI/IMID) showed a significant increase, whereas patients with inflammatory arthritis (IA) or systemic lupus erythematosus did not. COVID-19 cases in some but not all diagnostic groups had older ages than cases in the reference population. Patients with IA on targeted-synthetic or biological disease-modifying antirheumatic drugs (DMARDs), but not those on conventional-synthetic DMARDs, had a greater prevalence despite a similar age distribution. CONCLUSION: Patients with AI/IMID show a variable risk of hospital-diagnosed COVID-19. Interplay of ageing, therapies and disease-specific factors seem to contribute. These data provide a basis to improve preventive recommendations to rheumatic patients and to analyse the specific factors involved in COVID-19 susceptibility.|*Betacoronavirus[MESH]|Adult[MESH]|Age Distribution[MESH]|Aged[MESH]|Antirheumatic Agents/adverse effects[MESH]|Arthritis, Rheumatoid/drug therapy/epidemiology/virology[MESH]|Autoimmune Diseases/drug therapy/*epidemiology/virology[MESH]|COVID-19[MESH]|Coronavirus Infections/diagnosis/*epidemiology/virology[MESH]|Female[MESH]|Hospitalization/*statistics & numerical data[MESH]|Humans[MESH]|Lupus Erythematosus, Systemic/drug therapy/epidemiology/virology[MESH]|Male[MESH]|Middle Aged[MESH]|Pandemics[MESH]|Pneumonia, Viral/diagnosis/*epidemiology/virology[MESH]|Polymerase Chain Reaction[MESH]|Prevalence[MESH]|Retrospective Studies[MESH]|Rheumatic Diseases/drug therapy/*epidemiology/virology[MESH]|SARS-CoV-2[MESH]
  
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