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10.1016/j.meegid.2020.104419 http://scihub22266oqcxt.onion/10.1016/j.meegid.2020.104419 32540428!7290210!32540428     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32540428&cmd=llinks): Failed to open stream: HTTP request failed! 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Eltrombopag is a potential target for drug intervention in SARS-CoV-2 spike protein |pdf=|usr=}}{{32540428}} gab.com Text Eltrombopag is a potential target for drug intervention in SARS-CoV-2 spike protein JO: Infect Genet Evol http://www.kidney.de/pget.php?&tw=1&pmid=32540428 #FOAvip The COVID-19 pandemic, caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), is a current global threat for which there is an urgent need to search for an effective therapy. The transmembrane spike (S) glycoprotein of SARS-CoV-2 directly binds to the host angiotensin-converting enzyme 2 (ACE2) and mediates viral entrance, which is therefore considered as a promising drug target. Considering that new drug development is a time-consuming process, drug repositioning may facilitate rapid drug discovery dealing with sudden infectious diseases. Here, we compared the differences between the virtual structural proteins of SARS-CoV-2 and SARS-CoV, and selected a pocket mainly localizing in the fusion cores of S2 domain for drug screening. A virtual drug design algorithm screened the Food and Drug Administration-approved drug library of 1234 compounds, and 13 top scored compounds were obtained through manual screening. Through in vitro molecular interaction experiments, eltrombopag was further verified to possess a high binding affinity to S protein plus human ACE2 and could potentially affect the stability of the ACE2-S protein complex. Hence, it is worth further exploring eltrombopag as a potential drug for the treatment of SARS-CoV-2 infection. Twit Text FOAVip Eltrombopag is a potential target for drug intervention in SARS-CoV-2 spike protein ????Infect Genet Evol http://www.kidney.de/pget.php?&tw=1&pmid=32540428 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32540428 #FOAvip English Wikipedia <ref>{{Cite pmid|32540428}}</ref> Eltrombopag is a potential target for drug intervention in SARS-CoV-2 spike protein #MMPMID32540428 Feng S; Luan X; Wang Y; Wang H; Zhang Z; Wang Y; Tian Z; Liu M; Xiao Y; Zhao Y; Zhou R; Zhang S Infect Genet Evol 2020[Nov]; 85 (�): 104419 PMID32540428show ga The COVID-19 pandemic, caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), is a current global threat for which there is an urgent need to search for an effective therapy. The transmembrane spike (S) glycoprotein of SARS-CoV-2 directly binds to the host angiotensin-converting enzyme 2 (ACE2) and mediates viral entrance, which is therefore considered as a promising drug target. Considering that new drug development is a time-consuming process, drug repositioning may facilitate rapid drug discovery dealing with sudden infectious diseases. Here, we compared the differences between the virtual structural proteins of SARS-CoV-2 and SARS-CoV, and selected a pocket mainly localizing in the fusion cores of S2 domain for drug screening. A virtual drug design algorithm screened the Food and Drug Administration-approved drug library of 1234 compounds, and 13 top scored compounds were obtained through manual screening. Through in vitro molecular interaction experiments, eltrombopag was further verified to possess a high binding affinity to S protein plus human ACE2 and could potentially affect the stability of the ACE2-S protein complex. Hence, it is worth further exploring eltrombopag as a potential drug for the treatment of SARS-CoV-2 infection. |Algorithms[MESH] |Angiotensin-Converting Enzyme 2/chemistry/*metabolism[MESH] |Benzoates/chemistry/*pharmacology[MESH] |Computer Simulation[MESH] |Drug Design[MESH] |Drug Repositioning[MESH] |Humans[MESH] |Hydrazines/chemistry/*pharmacology[MESH] |Models, Molecular[MESH] |Protein Binding[MESH] |Protein Stability[MESH] |Pyrazoles/chemistry/*pharmacology[MESH] |SARS-CoV-2/drug effects/*metabolism[MESH] |Severe acute respiratory syndrome-related coronavirus/drug effects/*metabolism[MESH] |Spike Glycoprotein, Coronavirus/*chemistry/*metabolism[MESH]Eltrombopag is a potential target for drug intervention in SARS-CoV-2 (epmc).pdf DeepDyve Pubget Overpricing