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10.1016/j.jaip.2020.06.013 http://scihub22266oqcxt.onion/10.1016/j.jaip.2020.06.013 32565226!7303032!32565226     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32565226&cmd=llinks): Failed to open stream: HTTP request failed! 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Prompt Predicting of Early Clinical Deterioration of Moderate-to-Severe COVID-19 Patients: Usefulness of a Combined Score Using IL-6 in a Preliminary Study |pdf=|usr=}}{{32565226}} gab.com Text Prompt Predicting of Early Clinical Deterioration of Moderate-to-Severe COVID-19 Patients: Usefulness of a Combined Score Using IL-6 in a Preliminary Study JO: J Allergy Clin Immunol Pract http://www.kidney.de/pget.php?&tw=1&pmid=32565226 #FOAvip BACKGROUND: The early identification of patients at risk of clinical deterioration is of interest considering the timeline of COVID-19 after the onset of symptoms. OBJECTIVE: The aim of our study was to evaluate the usefulness of testing serum IL-6 and other serological and clinical biomarkers, to predict a short-term negative clinical course of patients with noncritical COVID-19. METHODS: A total of 208 patients with noncritical COVID-19 pneumonia at admission were consecutively enrolled. Clinical and laboratory findings obtained on admission were analyzed by using survival analysis and stepwise logistic regression for variable selection. Three-day worsening as outcome in a logistic model to generate a prognostic score was used. RESULTS: Clinical worsening occurred in 63 patients (16 = died; 39 = transferred to intensive care unit; 8 worsening of respiratory failure). Forty-five of them worsened within 3 days after admission. The risk of clinical worsening was progressively enhanced along with increasing quartiles of IL-6 levels. Multivariate analysis showed that IL-6 (P = .005), C-reactive protein (CRP) (P = .003), and SaO(2)/FiO(2) (P = .014) were the best predictors for clinical deterioration in the first 3 days after admission. The combined score yielded an area under the curve = 0.88 (95% confidence interval: 0.83-0.93). A nomogram predicting the probability of 3-day worsening was generated. The score also showed good performance for 7-day and 14- or 21-day worsening and in predicting death occurring during all the follow-up. CONCLUSIONS: Combining IL-6, CRP, and SaO(2)/FiO(2) in a score may help clinicians to identify on admission those patients with COVID-19 who are at high risk for a further 3-day clinical deterioration. Twit Text FOAVip Prompt Predicting of Early Clinical Deterioration of Moderate-to-Severe COVID-19 Patients: Usefulness of a Combined Score Using IL-6 in a Preliminary Study ????J Allergy Clin Immunol Pract http://www.kidney.de/pget.php?&tw=1&pmid=32565226 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32565226 #FOAvip English Wikipedia <ref>{{Cite pmid|32565226}}</ref> Prompt Predicting of Early Clinical Deterioration of Moderate-to-Severe COVID-19 Patients: Usefulness of a Combined Score Using IL-6 in a Preliminary Study #MMPMID32565226 Vultaggio A; Vivarelli E; Virgili G; Lucenteforte E; Bartoloni A; Nozzoli C; Morettini A; Berni A; Malandrino D; Rossi O; Nencini F; Pieralli F; Peris A; Lagi F; Scocchera G; Spinicci M; Trotta M; Mazzetti M; Parronchi P; Cosmi L; Liotta F; Fontanari P; Mazzoni A; Salvati L; Maggi E; Annunziato F; Almerigogna F; Matucci A J Allergy Clin Immunol Pract 2020[Sep]; 8 (8): 2575-2581.e2 PMID32565226show ga BACKGROUND: The early identification of patients at risk of clinical deterioration is of interest considering the timeline of COVID-19 after the onset of symptoms. OBJECTIVE: The aim of our study was to evaluate the usefulness of testing serum IL-6 and other serological and clinical biomarkers, to predict a short-term negative clinical course of patients with noncritical COVID-19. METHODS: A total of 208 patients with noncritical COVID-19 pneumonia at admission were consecutively enrolled. Clinical and laboratory findings obtained on admission were analyzed by using survival analysis and stepwise logistic regression for variable selection. Three-day worsening as outcome in a logistic model to generate a prognostic score was used. RESULTS: Clinical worsening occurred in 63 patients (16 = died; 39 = transferred to intensive care unit; 8 worsening of respiratory failure). Forty-five of them worsened within 3 days after admission. The risk of clinical worsening was progressively enhanced along with increasing quartiles of IL-6 levels. Multivariate analysis showed that IL-6 (P = .005), C-reactive protein (CRP) (P = .003), and SaO(2)/FiO(2) (P = .014) were the best predictors for clinical deterioration in the first 3 days after admission. The combined score yielded an area under the curve = 0.88 (95% confidence interval: 0.83-0.93). A nomogram predicting the probability of 3-day worsening was generated. The score also showed good performance for 7-day and 14- or 21-day worsening and in predicting death occurring during all the follow-up. CONCLUSIONS: Combining IL-6, CRP, and SaO(2)/FiO(2) in a score may help clinicians to identify on admission those patients with COVID-19 who are at high risk for a further 3-day clinical deterioration. |*Clinical Deterioration[MESH] |Adult[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |Betacoronavirus[MESH] |Biomarkers[MESH] |C-Reactive Protein/analysis[MESH] |COVID-19[MESH] |Comorbidity[MESH] |Coronavirus Infections/blood/*epidemiology/mortality/*physiopathology[MESH] |Female[MESH] |Humans[MESH] |Interleukin-6/*blood[MESH] |Kaplan-Meier Estimate[MESH] |Length of Stay[MESH] |Male[MESH] |Middle Aged[MESH] |Oxygen/blood[MESH] |Pandemics[MESH] |Pneumonia, Viral/blood/*epidemiology/mortality/*physiopathology[MESH] |ROC Curve[MESH] |Retrospective Studies[MESH] |SARS-CoV-2[MESH] |Time Factors[MESH]Prompt Predicting of Early Clinical Deterioration of Moderate-to-Sever(epmc).pdf DeepDyve Pubget Overpricing