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10.21037/atm-20-2429 http://scihub22266oqcxt.onion/10.21037/atm-20-2429 32566569!7290614!32566569     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32566569&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\32566569.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Ann+Transl+Med 2020 ; 8 (10): 632 Nephropedia Template TP {{tp|p=32566569|t=2020. Appealing for efficient, well organized clinical trials on COVID-19 |pdf=|usr=}}{{32566569}} gab.com Text Appealing for efficient, well organized clinical trials on COVID-19 JO: Ann Transl Med http://www.kidney.de/pget.php?&tw=1&pmid=32566569 #FOAvip BACKGROUND: The rapid emergence of clinical trials on COVID-19 stimulated a wave of discussion in scientific community. It is important to understand the characteristics of the ongoing or pending interventional clinical trials on COVID-19. METHODS: We reviewed the characteristics of interventional trials from Chinese Clinical Trial Registration (ChiCTR) and ClinicalTrials.gov. A total of 171 COVID-19-related interventional trials were identified on Feb 22, 2020. These trials are classified into 4 categories based on treatment modalities, including chemical drugs (CDs), biological therapies (BTs), traditional Chinese medicine (TCM) treatments and other therapies. RESULTS: Our analysis focused on the issues of stage, design, randomization, blinding, primary endpoints (PEs) definition and sample size of these trials. Although most trials use parallel-arm design (88.3%) and randomization (77.2%), blinding is applied in only 25 trials (14.6%). More than half of the trials planned to recruit </=100 patients, indicating a possibility of insufficient statistical power. About one third of trials will recruit severe and critically ill patients. More trials on traditional Chinese medical treatment use 2 or more PEs than those on CDs or biological treatments (57.6%, 39.4% and 40.5%, respectively). CONCLUSIONS: We found some studies with potential defects including unreasonable design, inappropriate PE and small sample size. Clinical trials on COVID-19 should be designed based on scientific rules, ethics and benefits for patients. Twit Text FOAVip Appealing for efficient, well organized clinical trials on COVID-19 ????Ann Transl Med http://www.kidney.de/pget.php?&tw=1&pmid=32566569 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32566569 #FOAvip English Wikipedia <ref>{{Cite pmid|32566569}}</ref> Appealing for efficient, well organized clinical trials on COVID-19 #MMPMID32566569 Zhao Y; Wei Y; Shen S; Zhang M; Chen F Ann Transl Med 2020[May]; 8 (10): 632 PMID32566569show ga BACKGROUND: The rapid emergence of clinical trials on COVID-19 stimulated a wave of discussion in scientific community. It is important to understand the characteristics of the ongoing or pending interventional clinical trials on COVID-19. METHODS: We reviewed the characteristics of interventional trials from Chinese Clinical Trial Registration (ChiCTR) and ClinicalTrials.gov. A total of 171 COVID-19-related interventional trials were identified on Feb 22, 2020. These trials are classified into 4 categories based on treatment modalities, including chemical drugs (CDs), biological therapies (BTs), traditional Chinese medicine (TCM) treatments and other therapies. RESULTS: Our analysis focused on the issues of stage, design, randomization, blinding, primary endpoints (PEs) definition and sample size of these trials. Although most trials use parallel-arm design (88.3%) and randomization (77.2%), blinding is applied in only 25 trials (14.6%). More than half of the trials planned to recruit äAppealing for efficient, well organized clinical trials on COVID-19 (epmc).pdf DeepDyve Pubget Overpricing