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10.1186/s12916-020-01624-8 http://scihub22266oqcxt.onion/10.1186/s12916-020-01624-8 32586391!7315698!32586391     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32586391&cmd=llinks): Failed to open stream: HTTP request failed! 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Addressing challenges for clinical research responses to emerging epidemics and pandemics: a scoping review |pdf=|usr=}}{{32586391}} gab.com Text Addressing challenges for clinical research responses to emerging epidemics and pandemics: a scoping review JO: BMC Med http://www.kidney.de/pget.php?&tw=1&pmid=32586391 #FOAvip BACKGROUND: Major infectious disease outbreaks are a constant threat to human health. Clinical research responses to outbreaks generate evidence to improve outcomes and outbreak control. Experiences from previous epidemics have identified multiple challenges to undertaking timely clinical research responses. This scoping review is a systematic appraisal of political, economic, administrative, regulatory, logistical, ethical and social (PEARLES) challenges to clinical research responses to emergency epidemics and solutions identified to address these. METHODS: A scoping review. We searched six databases (MEDLINE, Embase, Global Health, PsycINFO, Scopus and Epistemonikos) for articles published from 2008 to July 2018. We included publications reporting PEARLES challenges to clinical research responses to emerging epidemics and pandemics and solutions identified to address these. Two reviewers screened articles for inclusion, extracted and analysed the data. RESULTS: Of 2678 articles screened, 76 were included. Most presented data relating to the 2014-2016 Ebola virus outbreak or the H1N1 outbreak in 2009. The articles related to clinical research responses in Africa (n = 37), Europe (n = 8), North America (n = 5), Latin America and the Caribbean (n = 3) and Asia (n = 1) and/or globally (n = 22). A wide range of solutions to PEARLES challenges was presented, including a need to strengthen global collaborations and coordination at all levels and develop pre-approved protocols and equitable frameworks, protocols and standards for emergencies. Clinical trial networks and expedited funding and approvals were some solutions implemented. National ownership and community engagement from the outset were a key enabler for delivery. Despite the wide range of recommended solutions, none had been formally evaluated. CONCLUSIONS: To strengthen global preparedness and response to the COVID-19 pandemic and future epidemics, identified solutions for rapid clinical research deployment, delivery, and dissemination must be implemented. Improvements are urgently needed to strengthen collaborations, funding mechanisms, global and national research capacity and capability, targeting regions vulnerable to epidemics and pandemics. Solutions need to be flexible to allow timely adaptations to context, and research led by governments of affected regions. Research communities globally need to evaluate their activities and incorporate lessons learnt to refine and rehearse collaborative outbreak response plans in between epidemics. Twit Text FOAVip Addressing challenges for clinical research responses to emerging epidemics and pandemics: a scoping review ????BMC Med http://www.kidney.de/pget.php?&tw=1&pmid=32586391 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32586391 #FOAvip English Wikipedia <ref>{{Cite pmid|32586391}}</ref> Addressing challenges for clinical research responses to emerging epidemics and pandemics: a scoping review #MMPMID32586391 Sigfrid L; Maskell K; Bannister PG; Ismail SA; Collinson S; Regmi S; Blackmore C; Harriss E; Longuere KS; Gobat N; Horby P; Clarke M; Carson G BMC Med 2020[Jun]; 18 (1): 190 PMID32586391show ga BACKGROUND: Major infectious disease outbreaks are a constant threat to human health. Clinical research responses to outbreaks generate evidence to improve outcomes and outbreak control. Experiences from previous epidemics have identified multiple challenges to undertaking timely clinical research responses. This scoping review is a systematic appraisal of political, economic, administrative, regulatory, logistical, ethical and social (PEARLES) challenges to clinical research responses to emergency epidemics and solutions identified to address these. METHODS: A scoping review. We searched six databases (MEDLINE, Embase, Global Health, PsycINFO, Scopus and Epistemonikos) for articles published from 2008 to July 2018. We included publications reporting PEARLES challenges to clinical research responses to emerging epidemics and pandemics and solutions identified to address these. Two reviewers screened articles for inclusion, extracted and analysed the data. RESULTS: Of 2678 articles screened, 76 were included. Most presented data relating to the 2014-2016 Ebola virus outbreak or the H1N1 outbreak in 2009. The articles related to clinical research responses in Africa (n = 37), Europe (n = 8), North America (n = 5), Latin America and the Caribbean (n = 3) and Asia (n = 1) and/or globally (n = 22). A wide range of solutions to PEARLES challenges was presented, including a need to strengthen global collaborations and coordination at all levels and develop pre-approved protocols and equitable frameworks, protocols and standards for emergencies. Clinical trial networks and expedited funding and approvals were some solutions implemented. National ownership and community engagement from the outset were a key enabler for delivery. Despite the wide range of recommended solutions, none had been formally evaluated. CONCLUSIONS: To strengthen global preparedness and response to the COVID-19 pandemic and future epidemics, identified solutions for rapid clinical research deployment, delivery, and dissemination must be implemented. Improvements are urgently needed to strengthen collaborations, funding mechanisms, global and national research capacity and capability, targeting regions vulnerable to epidemics and pandemics. Solutions need to be flexible to allow timely adaptations to context, and research led by governments of affected regions. Research communities globally need to evaluate their activities and incorporate lessons learnt to refine and rehearse collaborative outbreak response plans in between epidemics. |*Biomedical Research[MESH] |*Disease Outbreaks[MESH] |*Epidemics[MESH] |*Pandemics[MESH] |Betacoronavirus[MESH] |COVID-19[MESH] |Coronavirus Infections/epidemiology[MESH] |Delivery of Health Care/organization & administration[MESH] |Ebolavirus[MESH] |Global Health[MESH] |Health Services Needs and Demand/*trends[MESH] |Humans[MESH] |Influenza A Virus, H1N1 Subtype[MESH] |Pneumonia, Viral/epidemiology[MESH]Addressing challenges for clinical research responses to emerging epid(epmc).pdf DeepDyve Pubget Overpricing