
| 10.1002/jmv.26232
http://scihub22266oqcxt.onion/10.1002/jmv.26232
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J+Med+Virol 2021 ; 93 (1): 250-256 Nephropedia Template TP
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The cytokine storm and COVID-19 #MMPMID32592501Hu B; Huang S; Yin LJ Med Virol 2021[Jan]; 93 (1): 250-256 PMID32592501show ga
Coronavirus disease 2019 (COVID-19), which began in Wuhan, China, in December 2019, has caused a large global pandemic and poses a serious threat to public health. More than 4 million cases of COVID-19, which is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), have been confirmed as of 11 May 2020. SARS-CoV-2 is a highly pathogenic and transmissible coronavirus that primarily spreads through respiratory droplets and close contact. A growing body of clinical data suggests that a cytokine storm is associated with COVID-19 severity and is also a crucial cause of death from COVID-19. In the absence of antivirals and vaccines for COVID-19, there is an urgent need to understand the cytokine storm in COVID-19. Here, we have reviewed the current understanding of the features of SARS-CoV-2 and the pathological features, pathophysiological mechanisms, and treatments of the cytokine storm induced by COVID-19. In addition, we suggest that the identification and treatment of the cytokine storm are important components for rescuing patients with severe COVID-19.|COVID-19 Drug Treatment[MESH]|COVID-19/*immunology/physiopathology[MESH]|Clinical Trials as Topic[MESH]|Cytokine Release Syndrome/*drug therapy/*virology[MESH]|Humans[MESH]|Lung/immunology/*pathology/virology[MESH]
  
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